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Titolo:
Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer
Autore:
Kakolyris, S; Giatromanolaki, A; Koukourakis, M; Powis, G; Souglakos, J; Sivridis, E; Georgoulias, V; Gatter, KC; Harris, AL;
Indirizzi:
Univ Gen Hosp Heraklion, Dept Clin Oncol, Iraklion 71110, Greece Univ Gen Hosp Heraklion Iraklion Greece 71110 ol, Iraklion 71110, Greece Democritus Univ Thrace, Dept Pathol, G-8100 Alexandroupolis, Greece Democritus Univ Thrace Alexandroupolis Greece G-8100 androupolis, Greece Univ Gen Hosp Larissa, Dept Radiotherapy & Oncol, Larisa 41222, Greece Univ Gen Hosp Larissa Larisa Greece 41222 & Oncol, Larisa 41222, Greece Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 , Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Oxford, John Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU Cellular Sci, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, Oncol Mol Lab, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ncol Mol Lab, Oxford OX3 9DU, England
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 10, volume: 7, anno: 2001,
pagine: 3087 - 3091
SICI:
1078-0432(200110)7:10<3087:TEIAWL>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING ACTIVITY; REDOX REGULATION; HUMAN TUMORS; PROTEIN; IMMUNOHISTOCHEMISTRY; STIMULATION; ACTIVATION; REDUCTASE; MECHANISM; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kakolyris, S Univ Hosp Heraklion, Dept Med Oncol, POB 1352, Iraklion 71110, Greece Univ Hosp Heraklion POB 1352 Iraklion Greece 71110 0, Greece
Citazione:
S. Kakolyris et al., "Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer", CLIN CANC R, 7(10), 2001, pp. 3087-3091

Abstract

Purpose: Thioredoxin (TRX), a low molecular weight protein, exerts reduction- oxidation control over a number of transcription factors involved in cell activation and proliferation. High TRX mRNA levels have been found in lung carcinomas, a trait associated with a growth and survival advantage. Experimental Design: In this study, we examined the immunohistochemical expression of human TRX in normal lung and in 102 primary non-small cell lungcarcinomas. Results: In normal lung, the staining for TRX was cytoplasmic in the respiratory bronchial epithelium, alveolar epithelium, and alveolar macrophages. Bronchial glandular cells demonstrated a mixed nuclear and cytoplasmic staining. In lung carcinomas, the pattern of expression for TRX was predominantly cytoplasmic and only occasionally nuclear. A strong association betweenabsence of TRX expression and regional lymph node negativity was observe (P = 0.004). High proliferation index, as detected with Ki-67 antibody, was associated with high TRX expression (P = 0.02). A significant correlation between high cytoplasmic p53 reactivity and low TRX expression was observed (P = 0.04). No association with grade, tumor stage, histology, or bcl-2 wasnoted. A significant coexpression of TRX with human activator protein endonuclease I was recorded (P = 0.04). Absence of TRX expression was associated with a better outcome (P < 0.05). Conclusions: We conclude that overexpression of TRX in non-small cell lungcarcinomas is indicative of a more aggressive tumor phenotype and is associated with bad prognostic features and possibly with a poorer outcome.

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Documento generato il 12/07/20 alle ore 06:09:06