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Titolo:
Corneal endothelial response to induced myopia in the chicken
Autore:
Hirst, LW; Bancroft, J; Bi, CJQ; Ohlrich, S;
Indirizzi:
Univ Queensland, Dept Surg, Div Ophthalmol, St Lucia, Qld, Australia Univ Queensland St Lucia Qld Australia thalmol, St Lucia, Qld, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
fascicolo: 4, volume: 29, anno: 2001,
pagine: 244 - 247
SICI:
1442-6404(200108)29:4<244:CERTIM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT;
Keywords:
chicken; corneal endothelium; hypertrophy; induced myopia; mitosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Hirst, LW Princess Alexandra Hosp, Div Ophthalmol, 2nd Floor,Lions Res Bldg, Brisbane, Qld 4102, Australia Princess Alexandra Hosp 2nd Floor,Lions Res Bldg Brisbane Qld Australia 4102
Citazione:
L.W. Hirst et al., "Corneal endothelial response to induced myopia in the chicken", CLIN EXP OP, 29(4), 2001, pp. 244-247

Abstract

Purpose: To investigate the role of corneal endothelial surface enlargement in the chicken myopia model in inducing corneal endothelial changes. Methods: Lid suture was performed on one eye of 1-day-old cockerels. Five chickens were killed at 1 week, and four chickens killed at each of 3 weeks, 6 weeks, and 10 weeks postnatal. The endothelial morphology was obtained by flat mounting the endothelial surface and the subsequent digitisation. Comparisons were undertaken between the control unsutured eye and the lid-sutured eye endothelium, and between the central endothelial areas compared to the peripheral endothelial areas in both the myopic and the normal corneas. Calculation of the contribution to the endothelial change by hypertrophyand mitosis were calculated using Bahn's formula. Results: Total endothelial surface area increased significantly over time in the myopic model compared to control eyes but the mean cell area of endothelial cells remained the same for both the enlarged myopic endothelial surface area and in the normal controls. Sampling from the central and the peripheral corneal endothelial surface also disclosed no difference. The meancell area did increase steadily with age but was the same for both normal and myopic corneas. Conclusions: It would appear that there are equal contributions from hypertrophy and mitosis in the myopic group and the normal corneal group with a slightly increasing trend towards mitotic activity in the myopic corneal endothelial layer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:15:09