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Titolo:
Scedosporium endophthalmitis: two fatal disseminated cases of Scedosporiuminfection presenting with endophthalmitis
Autore:
McKelvie, PA; Wong, EY; Chow, LP; Hall, AJ;
Indirizzi:
St Vincents Hosp, Dept Anat Pathol, Fitzroy, Vic 3065, Australia St Vincents Hosp Fitzroy Vic Australia 3065 Fitzroy, Vic 3065, Australia Royal Melbourne Hosp, Parkville, Vic 3050, Australia Royal Melbourne HospParkville Vic Australia 3050 le, Vic 3050, Australia Royal Victorian Eye & Ear Hosp, Melbourne, Vic, Australia Royal Victorian Eye & Ear Hosp Melbourne Vic Australia e, Vic, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
fascicolo: 5, volume: 29, anno: 2001,
pagine: 330 - 334
SICI:
1442-6404(200110)29:5<330:SETFDC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; PROLIFICANS; APIOSPERMUM; INFLATUM; LEUKEMIA;
Keywords:
acute myeloid leukaemia; disseminated fatal infection; endophthalmitis; Scedosporium apiospermum; Scedosporium prolificans;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: McKelvie, PA St Vincents Hosp, Dept Anat Pathol, 41 Victoria Parade, Fitzroy, Vic 3065,Australia St Vincents Hosp 41 Victoria Parade Fitzroy Vic Australia 3065
Citazione:
P.A. McKelvie et al., "Scedosporium endophthalmitis: two fatal disseminated cases of Scedosporiuminfection presenting with endophthalmitis", CLIN EXP OP, 29(5), 2001, pp. 330-334

Abstract

The incidence of disseminated infection with Scedosporium species is increasing in patients with haematological malignancy. Two fatal cases are reported of patients with acute myeloid leukaemia and neutropenia who presented with Scedosporium endophthalmitis. Diagnosis of fungal infection was delayed as blood and vitreous cultures were positive only after 3 days in patient1 and blood culture was positive at 7 days in patient 2. Despite antifungal therapy with amphotericin B and additional fluconazole in patient 2, bothpatients died of overwhelming fungal septicaemia. Post-mortem examination of the right globe in patient 1 showed haemorrhagic necrotizing chorioretinitis with numerous fungal hyphae in choroidal vessels, choroid, retina and vitreous. Scedosporium species are often resistant to conventional antifungal therapy including amphotericin B. Diagnosis is difficult and mortality in disseminated infection is high.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:09:03