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Titolo:
Lack of effect of gender on retinopathy in the mouse
Autore:
Higgins, RD; Yan, Y; Tadesse, M; Yossuck, P;
Indirizzi:
Georgetown Univ, Childrens Med Ctr, Dept Paediat, Div Neonatol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 eonatol, Washington, DC 20007 USA
Titolo Testata:
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
fascicolo: 5, volume: 29, anno: 2001,
pagine: 323 - 326
SICI:
1442-6404(200110)29:5<323:LOEOGO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-INDUCED RETINOPATHY; RISK-FACTORS; PREMATURITY; AGE;
Keywords:
angiogenesis; gender; mouse; oxygen; retinopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Higgins, RD Georgetown Univ, Childrens Med Ctr, Dept Paediat, Div Neonatol, 3800 Reservoir Rd,NW M3400, Washington, DC 20007 USA Georgetown Univ 3800Reservoir Rd,NW M3400 Washington DC USA 20007
Citazione:
R.D. Higgins et al., "Lack of effect of gender on retinopathy in the mouse", CLIN EXP OP, 29(5), 2001, pp. 323-326

Abstract

Background: The reported effect of gender on retinopathy of prematurity has been controversial. The goal of this study was to determine the effect ofgender on oxygen-induced retinopathy in a mouse model. Methods: Oxygen-induced retinopathy was produced in C57BL6 mice by exposure to 75% oxygen from postnatal day (P) 7 for 5 days. Animals were returned to room air on P12 and killed on P17-21. Gender was determined by inspection. Retinopathy was evaluated by a retinopathy scoring system and by quantification of extraretinal neovascular nuclei on retinal sections. Results: Both males and females developed similar degrees of retinopathy. Males had a median total retinopathy score of 9 (25th, 75th quartile: 8, 11) and females had score of 9 (25th, 75th quartile: 7,10). Retinal subscoresof blood vessel growth, blood vessel tufts, extraretinal neovascularization, haemorrhage and blood vessel tortuosity were similar in both groups. Males and females had a similar number of neovascular nuclei on retinal sections. Conclusions: Gender does not alter the development of oxygen-induced retinopathy in the C57BL6 mouse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:52:50