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Titolo:
An association of cervical inflammation with high-grade cervical neoplasiain women infected with oncogenic human papillomavirus (HPV)
Autore:
Castle, PE; Hillier, SL; Rabe, LK; Hildesheim, A; Herrero, R; Bratti, MC; Sherman, ME; Burk, RD; Rodriguez, AC; Alfaro, M; Hutchinson, ML; Morales, J; Schiffman, M;
Indirizzi:
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA NCI BethesdaMD USA 20892 Epidemiol & Genet, NIH, Bethesda, MD 20892 USA Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 rod Sci, Pittsburgh, PA 15213 USA Magee Womens Res Inst, Pittsburgh, PA 15213 USA Magee Womens Res Inst Pittsburgh PA USA 15213 t, Pittsburgh, PA 15213 USA Caja Costarricense Seguro Social, San Jose 1000, Costa Rica Caja Costarricense Seguro Social San Jose Costa Rica 1000 00, Costa Rica Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA Albert Einstein Coll Med, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Coll Med, Bronx, NY 10461 USA Women & Infants Hosp Rhode Isl, Providence, RI 02905 USA Women & Infants Hosp Rhode Isl Providence RI USA 02905 ence, RI 02905 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 10, volume: 10, anno: 2001,
pagine: 1021 - 1027
SICI:
1055-9965(200110)10:10<1021:AAOCIW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISK-FACTORS; BACTERIAL VAGINOSIS; CANCER; POPULATION; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Castle, PE NCI, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,MSC 7234, Bethesda,MD 20892 USA NCI 6120 Execut Blvd,MSC 7234 Bethesda MD USA 20892D 20892 USA
Citazione:
P.E. Castle et al., "An association of cervical inflammation with high-grade cervical neoplasiain women infected with oncogenic human papillomavirus (HPV)", CANC EPID B, 10(10), 2001, pp. 1021-1027

Abstract

Previous reports of genital conditions, such as nonspecific genital infection/sore or vaginal discharge associated with cervical cancer (L. A. Brinton et al., J. Natl. Cancer Inst. (Bethesda), 79: 23-30, 1987; C. J. Jones etal., Cancer Res., 50: 3657-3662, 1990), suggest a possible link between either genital tract inflammation or changes in bacteria flora consistent with bacterial vaginosis (BV) and cervical cancer. To test whether changes in vaginal bacterial flora or the degree of cervical inflammation are associated with women having a human papillomavirus (HPV) infection or with women infected with oncogenic HPV having high-grade cervical lesions (high-grade squamous intraepithelial lesions or cancer), we conducted a case-control study of women < 50 years old enrolled in the Costa Rican natural history study of HPV and cervical neoplasia. To test whether BV and inflammation were associated with HPV DNA positivity, Analysis 1 was restricted to women with no or mild (low-grade or equivocal) cytological abnormalities, and the degree of inflammation and Nugent score (a measure of BV) were compared betweenwomen infected (it = 220) and not infected (it = 130) with HPV. To test whether BV and inflammation were associated with high-grade lesions, Analysis2 was restricted to women infected with oncogenic HPV, and the degree of inflammation and Nugent score were compared between women with (it = 95) andwithout (re = 158) high-grade cervical lesions. In Analysis 1, BV and cervical inflammation were not associated with HPV infection. In Analysis 2, BVwas not associated with high-grade lesions. However, we found a marginallysignificant positive trend of increasing cervical inflammation associated with high-grade lesions in oncogenic HPV-infected Women, (P-trend = 0.05). Overt cervicitis was associated with a 1.9-fold increase in risk of high-grade lesions (95% confidence interval, 0.90-4.1). The results of this study suggest that cervical inflammation may be associated with high-grade lesions and may be a cofactor for high-grade cervical lesions in women infected with oncogenic HPV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:54:21