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Titolo:
Fatigue during preoperative chemoradiation for resectable rectal cancer
Autore:
Wang, XS; Janjan, NA; Guo, H; Johnson, BA; Engstrom, MC; Crane, CH; Mendoza, TR; Cleeland, CS;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Pain Res Grp, Houston, TX 77030 USA UnivTexas Houston TX USA 77030 Ctr, Pain Res Grp, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USAUniv Texas Houston TX USA 77030 Dept Radiat Oncol, Houston, TX 77030 USA
Titolo Testata:
CANCER
fascicolo: 6, volume: 92, anno: 2001, supplemento:, S
pagine: 1725 - 1732
SICI:
0008-543X(20010915)92:6<1725:FDPCFR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEIVING RADIATION-THERAPY; ADJUVANT THERAPY; POSTOPERATIVE RADIOTHERAPY; COLORECTAL-CANCER; RANDOMIZED TRIAL; DOSE LEUCOVORIN; CARCINOMA; CHEMOTHERAPY; FLUOROURACIL; SURGERY;
Keywords:
rectal cancer; chemoradiation therapy; fatigue; repeated measure; ANOVA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, XS Univ Texas, MD Anderson Canc Ctr, Pain Res Grp, 1100 Holcombe Blvd,Box 221, Houston, TX 77030 USA Univ Texas 1100 Holcombe Blvd,Box 221 Houston TX USA 77030 30 USA
Citazione:
X.S. Wang et al., "Fatigue during preoperative chemoradiation for resectable rectal cancer", CANCER, 92(6), 2001, pp. 1725-1732

Abstract

BACKGROUND. The aim of this study was to evaluate the severity and patterns of fatigue during preoperative chemoradiation therapy for locally advanced rectal cancer and determine whether there are predictors for patients whodevelop severe fatigue. METHODS. Seventy-two patients with resectable rectal cancer received chemoradiation (total radiation dose, 45 gray/25 fractions to the pelvis; continuous infusion of 5-fluorouracil [300 mg/m(2)]). The Brief Fatigue Inventory(BFI), a measure that categorizes fatigue severity on a 0-10 scale, was administered weekly during treatment. Severe fatigue was defined as 7-10 on the "worst level of fatigue" item. Demographics, disease information, toxicities, and blood counts were collected. Descriptive statistics, repeated measure analysis of variance, and multiple regression were used to examine fatigue and its correlates. RESULTS. Fatigue increased in 67% of patients during chemoradiation (CTX/XRT). The mean fatigue score increased from 3.16 before treatment to 4.62 atthe end of treatment. A significant linear trend suggested that fatigue progressively got worse during CTX/XRT (F = 16.4911, P < 0.001). However, 18%of patients experienced severe fatigue before CTX/XRT; this was predicted by uncontrolled pain (r(2) = 0.321; F = 16.52; P < 0.001). During CTX/XRT, uncontrolled diarrhea was the only predictor for increased fatigue (r(2) = 0.182; F = 7.77; P < 0.01). Approximately one-third of patients had severe fatigue, which impaired their function at the end of CTX/XRT. CONCLUSIONS. Preoperative chemoradiation therapy for patients with rectal cancer was associated with progressive fatigue during therapy. Based on identified predictors for fatigue, more active pain management before CXT/XRT and bowel management during CTX/XRT might reduce cancer-related fatigue in these patients. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:46:59