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Titolo:
Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum
Autore:
Hiroshima, K; Toyozaki, T; Iyoda, A; Yusa, T; Fujisawa, T; Ohwada, H;
Indirizzi:
Chiba Univ, Sch Med, Div Pathol, Inst Pulm Canc Res,Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 lm Canc Res,Chuo Ku, Chiba 2608670, Japan Chiba Univ, Sch Med, Div Surg, Inst Pulm Canc Res, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 Inst Pulm Canc Res, Chiba 2608670, Japan Chiba Rosai Hosp, Dept Resp Surg, Chiba, Japan Chiba Rosai Hosp Chiba Japan a Rosai Hosp, Dept Resp Surg, Chiba, Japan
Titolo Testata:
CANCER
fascicolo: 7, volume: 92, anno: 2001,
pagine: 1798 - 1806
SICI:
0008-543X(20011001)92:7<1798:AAPAIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-CELL TUMORS; ALPHA-FETOPROTEIN; BCL-2 EXPRESSION; PROGNOSTIC-SIGNIFICANCE; PROTEIN EXPRESSION; GASTRIC CARCINOMAS; TESTICULAR CANCER; SUPPRESSOR GENE; OVARIAN-CANCER; LUNG-CARCINOMA;
Keywords:
apoptosis; bcl-2; bax; p53; alpha-fetoprotein; mediastinum; teratoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hiroshima, K Chiba Univ, Sch Med, Div Pathol, Inst Pulm Canc Res,Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 2608670, Japan
Citazione:
K. Hiroshima et al., "Apoptosis and proliferative activity in mature and immature teratomas of the mediastinum", CANCER, 92(7), 2001, pp. 1798-1806

Abstract

BACKGROUND. Mediastinal teratomas are the most frequent mediastinal germ cell tumor. Whereas mature teratomas are benign tumors, immature teratomas are malignant. The purpose of this study was to find characteristics that could be used to distinguish between the growth and prognosis of the two teratoma types. METHODS. Twenty-four mediastinal teratomas (18 mature and 6 immature) wereexamined for apoptosis by 3 ' -end labeling of DNA and stained immunohistochemically for proliferating cell nuclear antigen, Bcl-2, Bax, p53 protein,and a-fetoprotein (AFP) expression in formalin fixed, paraffin embedded specimens. RESULTS. AFP was expressed in both immature teratomas and mature teratomas. Whereas p53 protein was expressed by most teratomas, p53 gene mutation was observed in only one patient with an immature teratoma in which the same mutation occurred in all tumor tissue components tested. Bax protein expression was relatively diffuse in mature teratomas but was focally expressed in immature teratomas. Bcl-2 protein was expressed focally in both mature and immature teratomas. Although the proliferative index was significantly higher in immature teratomas compared with mature teratomas (P < 0.001), the apoptotic index (AI) was significantly higher in mature teratomas compared with immature teratomas (P < 0.05). All patients except one in this study remain alive and disease free after undergoing tumor resection. CONCLUSIONS. The relatively high Al in mature teratomas may be due to the overexpression of the p53 protein. In contrast, immature teratomas exhibited higher proliferative activity and lower rates of apoptosis, which may explain the more aggressive behavior of these tumors. However, patients with immature mediastinal teratomas have a good prognosis if the tumor is resected completely after chemotherapy. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:54:13