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Titolo:
Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation
Autore:
Okazaki, MM; Nadler, JV;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 915, anno: 2001,
pagine: 58 - 69
SICI:
0006-8993(20011005)915:1<58:GRIIDG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; SYNAPTIC REORGANIZATION; TEMPORAL-LOBE; ENTORHINAL CORTEX; KAINATE RECEPTORS; PYRAMIDAL CELLS; FASCIA-DENTATA; PERFORANT PATH; TREATED RATS; KAINIC ACID;
Keywords:
mossy fiber; epilepsy; granule cell; hippocampus; glutamate receptors; DCG-IV; pilocarpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Nadler, JV Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Canc Biol, Durham, NC 27710 USA
Citazione:
M.M. Okazaki e J.V. Nadler, "Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation", BRAIN RES, 915(1), 2001, pp. 58-69

Abstract

In many persons with temporal lobe epilepsy, dentate granule cells form aninterconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule cell epileptiform activity evoked by stimulating the mossy fibers was investigated with use of rat hippocampal slices superfused with bicuculline. with or without increasing [K+](o) to 6 mM. The occurrence of short-latency mossy fiber-evoked granule cell epileptiform activity in slices from pilocarpine-treated rats correlated with the presence and extent of recurrent mossy fiber growth. Blockade of AMPA receptors nearly abolished the orthodromic component of the response;, subsequent antagonism of kainate receptors as well appeared to have no further action. Antagonism of NMDA receptors reduced the duration of epileptiform discharge, but increased the amplitude of population spikes within the evoked burst. Thus AMPA and NMDA, but perhaps not kainate, receptors play an important role in this type of epileptiform activity, Activation of type II metabotropic glutamate receptors, which inhibits the release of glutamate from mossy fiber boutons. reduced the magnitude of epileptiform discharge. This action was reversed by a partial agonist of these receptors. However, neither an agonist nor an antagonist of type III metabotropic glutamate receptors significantly alteredthe response. Considering the importance of synchronous granule cell discharge for seizure propagation from the entorhinal cortex to the hippocampus,agonists of type II metabotropic glutamate receptors may be useful in suppressing such discharge both experimentally and clinically. (C) 2001 Elsevier Science BY All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:37:27