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Titolo:
Autoradiographic mapping of 5-HT1B and 5-HT1D receptors in the post mortemhuman brain using [H-3]GR 125743
Autore:
Varnas, K; Hall, H; Bonaventure, P; Sedvall, G;
Indirizzi:
Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 Sect, S-17176 Stockholm, Sweden RW Johnson Pharmaceut Res Inst, San Diego, CA 92121 USA RW Johnson Pharmaceut Res Inst San Diego CA USA 92121 Diego, CA 92121 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 915, anno: 2001,
pagine: 47 - 57
SICI:
0006-8993(20011005)915:1<47:AMO5A5>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMORTEM HUMAN BRAIN; GUINEA-PIG BRAIN; BINDING-SITES; RAT-BRAIN; SEROTONIN RECEPTORS; MICE LACKING; ANTAGONISTS; 5-HYDROXYTRYPTAMINE; LOCALIZATION; DEPRESSION;
Keywords:
[H-3]GR 125743; 5-HT1B receptor; 5-HT1D receptor; human brains; whole hemisphere autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hall, H Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychiat Sect, S-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17176 17176 Stockholm, Sweden
Citazione:
K. Varnas et al., "Autoradiographic mapping of 5-HT1B and 5-HT1D receptors in the post mortemhuman brain using [H-3]GR 125743", BRAIN RES, 915(1), 2001, pp. 47-57

Abstract

The distribution of 5-HT1B and 5-HT1D receptors in the human post mortem brain was examined using whole hemisphere autoradiography and the radioligand [H-3]GR 125743. [H-3]GR 125743 binding was highest in the substantia nigra and the globus pallidus. Lower levels were detected in the striatum, withthe highest densities in the ventromedial parts. In the amygdala, the hippocampus, the septal region and the hypothalamus, lower [H-3]GR 125743 binding was observed. reflecting low densities of 5-HT1B/1D receptors. In the cerebral cortex, binding was similar in most regions, although restricted parts of the medial occipital cortex were markedly more densely labeled. Binding densities were very low in the cerebellar cortex and in the thalamus. Two methods were used to distinguish between the two receptor subtypes, the first using ketanserin to block 5-HT1D receptors and the second using SB 224289 to inhibit 5-HT1B receptor binding. The autoradiograms indicated that in the human brain, the 5-HT1B receptor is much more abundant than the 5-HT1D receptor, which seemed to occur only in low amounts mainly in the ventralpallidum. Although [H-3]GR 125743 is a suitable radioligand to examine thedistribution of 5-HT1B receptors in the human brain in vitro, the selectivities of ketanserin and SB 224289 are not sufficiently high to give definite evidence for the occurrence of the 5-HT1D receptor in the human brain. (C) 2001 Elsevier Science BY All rights reserved.

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Documento generato il 29/03/20 alle ore 14:24:58