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Titolo:
Brain mediation of Anolis social dominance displays III. Differential forebrain H-3-sumatriptan binding in dominant vs. submissive males
Autore:
Baxter, LR;
Indirizzi:
Univ Alabama, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Neurobiol, Birmingham, AL 35294 USA Univ Alabama, Dept Neurobiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Neurobiol, Birmingham, AL 35294 USA Univ Alabama, Dept Psychol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 pt Psychol, Birmingham, AL 35294 USA Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Yerkes Reg Primate Res Ctr, Atlanta, GA USA Yerkes Reg Primate Res Ctr Atlanta GA USA imate Res Ctr, Atlanta, GA USA
Titolo Testata:
BRAIN BEHAVIOR AND EVOLUTION
fascicolo: 4, volume: 57, anno: 2001,
pagine: 202 - 213
SICI:
0006-8977(200104)57:4<202:BMOASD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS MODULATE RELEASE; RAT STRIATAL SYNAPTOSOMES; DORSAL RAPHE NUCLEUS; GUINEA-PIG BRAIN; SEROTONIN RECEPTORS; 5-HT1B RECEPTORS; FUNCTIONAL EXPRESSION; KNOCKOUT MICE; BASAL GANGLIA; 5-HYDROXYTRYPTAMINE;
Keywords:
serotonin; 5-HT1B; 5-HT1D; territoriality; dominance; submission; Anolis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Baxter, LR 1001 Sparks Bldg,1720 7th Ave S, Birmingham, AL 35294 USA 1001Sparks Bldg,1720 7th Ave S Birmingham AL USA 35294 94 USA
Citazione:
L.R. Baxter, "Brain mediation of Anolis social dominance displays III. Differential forebrain H-3-sumatriptan binding in dominant vs. submissive males", BRAIN BEHAV, 57(4), 2001, pp. 202-213

Abstract

Measures of serotonin (5-HT) turnover in A. carolinensis forebrain increase acutely when males exhibit dominant social/territorial display routines, but decrease during submissive displays [Baxter et al., 2001a, b]. The present investigation sought to determine whether a difference in presynaptic regulatory receptors - one that might affect 5-HT flux - distinguish dominant vs. submissive anoles. Both 5-HT1B and 5-HT1D receptors are presynaptic regulators of output; this role is prominent at 5-HT terminals, where stimulation inhibits 5-HT release. Here, H-3-sumatriptan binding at sites similarto mammalian 5-HT1BD receptors was significantly higher in forebrain regions of submissive anoles than in dominant cagemates; this receptor site seemed pharmacologically more like a 5-HT1B than a 5-HT1D receptor. Higher densities of presynaptic 5-HT1B receptors in subordinates than in dominants might account for differences in 5-HT flux (lower in subordinates than in dominants) observed in displaying anoles of different status. Knockout mice missing the 5-HT1B receptor show heightened male territorial aggressiveness, thus similar 5-HT regulatory mechanisms might influence the likelihood of dominance in both mammals and reptiles. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:58:14