Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase
Autore:
Tillekeratne, LMV; Sherette, A; Grossman, P; Hupe, L; Hupe, D; Hudson, RA;
Indirizzi:
Univ Toledo, Coll Pharm, Dept Med & Biol Chem, Toledo, OH 43606 USA Univ Toledo Toledo OH USA 43606 ept Med & Biol Chem, Toledo, OH 43606 USA Pfizer Global Res & Dev, Ann Arbor, MI 48105 USA Pfizer Global Res & Dev Ann Arbor MI USA 48105 v, Ann Arbor, MI 48105 USA Univ Toledo, Coll Arts & Sci, Dept Biol, Toledo, OH 43606 USA Univ ToledoToledo OH USA 43606 ts & Sci, Dept Biol, Toledo, OH 43606 USA Univ Toledo, Coll Arts & Sci, Dept Chem, Toledo, OH 43606 USA Univ ToledoToledo OH USA 43606 ts & Sci, Dept Chem, Toledo, OH 43606 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 20, volume: 11, anno: 2001,
pagine: 2763 - 2767
SICI:
0960-894X(20011022)11:20<2763:SCIOHR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTIONS; THERAPY; DERIVATIVES; STRATEGIES; NNRTIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hudson, RA Univ Toledo, Coll Pharm, Dept Med & Biol Chem, 2801 W Bancroft St, Toledo,OH 43606 USA Univ Toledo 2801 W Bancroft St Toledo OH USA 43606 OH 43606 USA
Citazione:
L.M.V. Tillekeratne et al., "Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase", BIOORG MED, 11(20), 2001, pp. 2763-2767

Abstract

Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as theA17 double mutant (KI03N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 06:45:26