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Titolo:
Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: Preliminary report
Autore:
Reneman, L; Majoie, CBLM; Schmand, B; van den Brink, W; den Heeten, GJ;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Grad Sch Neurosci, Dept Nucl Med, NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZAmsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Radiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Amsterdam Inst Addict Res, NL-1105 BC Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 BC C Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 BC Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 BC C Amsterdam, Netherlands
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 50, anno: 2001,
pagine: 550 - 554
SICI:
0006-3223(20011001)50:7<550:PNISAW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MDMA ECSTASY; COGNITIVE PERFORMANCE; BRAIN; NEUROTOXICITY; NEURONS; MONKEYS;
Keywords:
MDMA; 5-HT; neurotoxicity; memory function; proton magnetic resonance spectroscopy; H-1-MRS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Reneman, L Univ Amsterdam, Acad Med Ctr, Grad Sch Neurosci, Dept Nucl Med,F2-210,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam F2-210,Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
L. Reneman et al., "Prefrontal N-acetylaspartate is strongly associated with memory performance in (abstinent) ecstasy users: Preliminary report", BIOL PSYCHI, 50(7), 2001, pp. 550-554

Abstract

Background: 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") is knownto damage brain serotonin neurons in animals and possibly humans. Because serotonergic damage may adversely affect memory, we compared verbal memory function between MDMA users and MDMA-naive control subjects and evaluated the relationship between verbal memory function and neuronal dysfunction in the MDMA users. Methods: An auditory verbal memory task (Rey Auditory Verbal Learning Test) was used to study eight abstinent MDMA users and seven control subjects. In addition H-1-MRS was used in different brain regions of all MDMA users to measure N-acetylaspartate/creatine (NAA/Cr) ratios, a marker for neuronalviability. Results: The MDMA users recalled significantly fewer words than control subjects on delayed (p = .03) but not immediate recall (p = .08). In MDMA users, delayed memory function was strongly associated with NAA/Cr only in theprefrontal cortex (R-2 = .76, p = .01). Conclusions: Greater decrements in memory function predicted lower NAA/Cr levels-and by inference greater neuronal dysfunction-in the prefrontal cortex of MDMA users. Biol Psychiatry 2001;50:550-554 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 22/01/20 alle ore 06:56:03