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Titolo:
Selective bilateral hippocampal volume loss in chronic schizophrenia
Autore:
Velakoulis, D; Stuart, GW; Wood, SJ; Smith, DJ; Brewer, WJ; Desmond, P; Singh, B; Copolov, D; Pantelis, C;
Indirizzi:
Mental Hlth Res Inst Victoria, Appl Schizophrenia Div, Melbourne, Vic, Australia Mental Hlth Res Inst Victoria Melbourne Vic Australia ne, Vic, Australia Univ Melbourne, Cognit Neuropsychiat Res & Acad Unit, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia d Unit, Melbourne, Vic, Australia Sunshine Hosp, Melbourne, Vic, Australia Sunshine Hosp Melbourne Vic Australia ne Hosp, Melbourne, Vic, Australia Royal Melbourne Hosp, Dept Psychiat, Neuropsychiat Unit, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia ychiat, Melbourne, Vic, Australia Univ Melbourne, Dept Radiol, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia Radiol, Melbourne, Vic, Australia
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 50, anno: 2001,
pagine: 531 - 539
SICI:
0006-3223(20011001)50:7<531:SBHVLI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPISODE SCHIZOPHRENIA; TEMPORAL-LOBE; PSYCHOSIS; REDUCTION; MEMORY; ABNORMALITIES; IMPAIRMENT; EPILEPSY; COMPLEX; SIZE;
Keywords:
schizophrenia; hippocampus; shape analysis; neuroimaging; diagnostic specificity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Velakoulis, D Mental Hlth Res Inst, Locked Bag 11, Parkville, Vic 3052, Australia Mental Hlth Res Inst Locked Bag 11 Parkville Vic Australia 3052
Citazione:
D. Velakoulis et al., "Selective bilateral hippocampal volume loss in chronic schizophrenia", BIOL PSYCHI, 50(7), 2001, pp. 531-539

Abstract

Background: The hippocampus is implicated in the pathophysiology of schizophrenia; however, volumetric changes are subtle and have limited diagnosticspecificity. It is possible that the shape of the hippocampus may be more characteristic of schizophrenia. Methods: Forty-five patients with chronic schizophrenia and 139 healthy, control subjects were scanned using magnetic resonance imaging. Hippocampi were traced manually, and two-dimensional shape information was analyzed. Results: Two shape factors were found to be adequate to represent variancein the shape of the hippocampus. One of these factors, representing volumeloss behind the head of the hippocampus, provided a degree of discrimination between patients with chronic schizophrenia and healthy control subjects; however, overall hippocampal volume following appropriate adjustment for brain volume showed a similar level of discrimination. Patients with chronic schizophrenia were best characterized using these two measures together, but diagnostic specificity was only moderate. Conclusions: This study identified that less of the hippocampus was distributed in its posterior two-thirds in patients with chronic schizophrenia, and specifically in the region just posterior to the hippocampal head. Groupdiscrimination on the basis of hippocampal volume and shape measures was moderately good. A full three-dimensional analysis of hippocampal shape, based on large samples, would be a useful extension of the study. Biot Psychiatry 2001;50:531-539 (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:58:37