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Titolo:
A comparison of symptom provocation procedures in psychiatry and other areas of medicine: Implications for their ethical use in research
Autore:
Avila, MT; Conley, RR; Carpenter, WT;
Indirizzi:
Maryland Psychiat Res Ctr, Schizophrenia Related Disorders Clin, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr Baltimore MD USA 21228 Baltimore, MD 21228 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 50, anno: 2001,
pagine: 479 - 486
SICI:
0006-3223(20011001)50:7<479:ACOSPP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINE RELEASE; MEDICATION DISCONTINUATION; TRYPTOPHAN DEPLETION; HEALTHY-SUBJECTS; CO2 CHALLENGE; SCHIZOPHRENIA; DISORDERS; KETAMINE; PERSPECTIVE; COMPETENCE;
Keywords:
symptom provocation; challenge study; ethics; psychiatric research; institutional review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Avila, MT Maryland Psychiat Res Ctr, Schizophrenia Related Disorders Clin,POB 21247, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr POB 21247 Baltimore MD USA 21228 8 USA
Citazione:
M.T. Avila et al., "A comparison of symptom provocation procedures in psychiatry and other areas of medicine: Implications for their ethical use in research", BIOL PSYCHI, 50(7), 2001, pp. 479-486

Abstract

Background: Symptom provocation is used to study a wide variety of medicaldisorders. In contrast to other areas of medicine, the application of these procedures to the study of mental disease has generated significant scientific, political, and public debate. Purported differences include an overabundance of these procedures in psychiatry and a lack of diagnostic and therapeutic utility. Accurate appraisal of these research designs is needed toaddress scientific merit and ethical concerns. This article provides a general review of challenge studies in several areas of medical research, compares purposes and methods to those used in psychiatry, and ascertains whether fundamental differences exist. Methods: In total, 655 challenge studies were identified using MEDLINE andPsychInfo Boolean key word searches. Information was collected from each study including the year of publication, whether subjects were healthy or patient volunteers, the disease being studied, and the study purpose (e.g., to study pathophysiology, test treatment efficacy, or diagnosis of a disorder). Results: Differences in study design, purpose, and frequency of studies across time were similar for medical and psychiatric diseases. Conclusions: Given extensive similarity in purpose and procedures, why arepsychiatric challenge studies being subjected to public criticism and special review and approval procedures? Several relevant issues are addressed including risk, scientific merit, and clinical application. Biol Psychiatry 2001;50:479-486 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 23/01/20 alle ore 06:19:48