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Titolo:
The role of immunoglobulins in neonatal rhesus haemolytic disease
Autore:
Greenough, A;
Indirizzi:
Univ London Kings Coll Hosp, Dept Child Hlth,Div Womens & Childrens Hlth, Guys Kings & St Thomas Med Sch, Children Nationwide Reg Neonatal Intens Care Ctr, London SE5 9RS, England Univ London Kings Coll Hosp London EnglandSE5 9RS ndon SE5 9RS, England
Titolo Testata:
BIODRUGS
fascicolo: 8, volume: 15, anno: 2001,
pagine: 533 - 541
SICI:
1173-8804(2001)15:8<533:TROIIN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE INTRAVENOUS IMMUNOGLOBULIN; ANTI-D IMMUNOGLOBULIN; IMMUNE HEMOLYTIC JAUNDICE; INTRAUTERINE TRANSFUSION; GAMMA-GLOBULIN; IN-VITRO; ISOIMMUNE THROMBOCYTOPENIA; HOST DISEASE; LATE ANEMIA; NEWBORN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Greenough, A Univ London Kings Coll Hosp, Dept Child Hlth,Div Womens & Childrens Hlth, Guys Kings & St Thomas Med Sch, Children Nationwide Reg Neonatal Intens Care Ctr, 4th Floor,Ruskin Wing, London SE5 9RS, England Univ London Kings Coll Hosp 4th Floor,Ruskin Wing London England SE5 9RS
Citazione:
A. Greenough, "The role of immunoglobulins in neonatal rhesus haemolytic disease", BIODRUGS, 15(8), 2001, pp. 533-541

Abstract

Rhesus (Rh) isoimmunisation is the most common form of severe haemolytic disease of the newborn (HDN). The introduction of prophylaxis with anti-D Rh0 immunoglobulin (anti-D) has resulted in a marked reduction in the sensitisation of Rh-negative women and deaths attributable to Rh HDN. The sensitisation rate could be further decreased if there was strict adherence to the guidelines for administration of anti-D prophylaxis. Whether additional prophylaxis at 28 and 34 weeks of gestation would be cost effective is controversial. Intrauterine transfusions to treat fetal anaemia, postnatal exchange transfusions and phototherapy are all part of the standard management of affected individuals. Intravenous immunoglobulin given to pregnant women can reduce fetal haemolysis, and when administered to neonates with Rh isoimmunisation has been associated with a reduction in the requirement for exchange transfusion. There are, however, potential risks of immunoglobulin administration, including haemolysis due to the presence of anti-A or anti-B antibodies, allergy and the transmission of disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:05:02