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Titolo:
Neuroendocrine and immune aspects of fibromyalgia
Autore:
van West, D; Maes, M;
Indirizzi:
State Univ Limburg Hosp, Dept Psychiat & Neuropsychol, NL-6202 AZ Maastricht, Netherlands State Univ Limburg Hosp Maastricht Netherlands NL-6202 AZt, Netherlands Clin Res Ctr Mental Hlth, Antwerp, Belgium Clin Res Ctr Mental Hlth Antwerp Belgium Mental Hlth, Antwerp, Belgium Vanderbilt Univ, Dept Psychiat, Nashville, TN USA Vanderbilt Univ Nashville TN USA Univ, Dept Psychiat, Nashville, TN USA
Titolo Testata:
BIODRUGS
fascicolo: 8, volume: 15, anno: 2001,
pagine: 521 - 531
SICI:
1173-8804(2001)15:8<521:NAIAOF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONNECTIVE-TISSUE DISEASE; PITUITARY-ADRENAL AXIS; ACTIVATED KILLER CELLS; HUMAN INTERFERON-ALPHA; BLIND CROSSOVER TRIAL; FIBROSITIS SYNDROME; SUBSTANCE-P; MAJOR DEPRESSION; ANTINUCLEAR ANTIBODIES; MUSCULOSKELETAL PAIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: van West, D State Univ Limburg Hosp, Dept Psychiat & Neuropsychol, Postbus5800, NL-6202 AZ Maastricht, Netherlands State Univ Limburg Hosp Postbus 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
D. van West e M. Maes, "Neuroendocrine and immune aspects of fibromyalgia", BIODRUGS, 15(8), 2001, pp. 521-531

Abstract

Fibromyalgia is a form of non-articular rheumatism characterised by long term (>3 months) and widespread musculoskeletal aching, stiffness and pressure hyperalgesia at characteristic soft tissue sites, called soft tissue tender points. The biophysiology of fibromyalgia, however, has remained elusive and the treatment remains mainly empirical. This article reviews the neuroendocrine-immune pathophysiology of fibromyalgia. There is no major evidence that fibromyalgia is accompanied by activation of the inflammatory response system, by immune activation or by an inflammatory process. There is some evidence that fibromyalgia is accompanied by some signs of immuno suppression, suggesting that immunomodifying drugs could have potential in the treatment of fibromyalgia. Recent trials with cytokines, such as interferon-a, have been undertaken in patients with fibromyalgia. Immunotherapy with these agents, however, may induce symptoms reminiscent of fibromyalgia and depression in a considerable number of patients. Lowered serum activity of prolyl endopeptidase (PEP), a cytosolic endopeptidase that cleaves peptide bonds on the carboxyl side of proline in proteins of relatively small molecular mass, may play a role in the biophysiology of fibromyalgia through diminished inactivation of algesic and depression-related peptides, e.g. substance P. Trials with PEP agonists could be worthwhile in fibromyalgia. The muscle energy depletion hypothesis of fibromyalgia is supported by findings that this condition is accompanied by lowered plasma levels of branched chainamino acids (BCAAs), i.e. valine, leucine and isoleucine. Since there is evidence that BCAA supplementation decreases muscle catabolism and has ergogenic values, a supplemental trial with BCAAs in fibromyalgia appears to be justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:44:28