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Titolo:
A vaccine against dental caries - An overview
Autore:
Michalek, SM; Katz, J; Childers, NK;
Titolo Testata:
BIODRUGS
fascicolo: 8, volume: 15, anno: 2001,
pagine: 501 - 508
SICI:
1173-8804(2001)15:8<501:AVADC->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL IMMUNE-SYSTEM; STREPTOCOCCUS-MUTANS GLUCOSYLTRANSFERASE; TOXIN-B-SUBUNIT; BACTERIAL PROTEIN ANTIGEN; ANTIBODY-PRODUCING CELLS; INFLUENZA-A VIRUS; CHOLERA-TOXIN; INTRANASAL IMMUNIZATION; PROTECTIVE IMMUNITY; IMMUNOGLOBULIN-A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Michalek et al., "A vaccine against dental caries - An overview", BIODRUGS, 15(8), 2001, pp. 501-508

Abstract

Dental caries continues to be a costly and prevalent oral disease. Research efforts towards developing a well tolerated and effective vaccine againstdental caries were initiated following the demonstration of a specific bacterial aetiology for this disease. The cariogenic mutans streptococci are the principal bacteria causing this disease. Specific immune defence againstthese bacteria is provided mainly by secretory immunoglobulin (Ig) A antibodies present in saliva, which are generated by the common mucosal immune system. Progress in the development of a vaccine against dental caries has increased due to both advancements in molecular biology and our understanding of the mucosal immune system and mucosal vaccines. Advancements in molecular biology have facilitated the cloning and functional characterisation ofvirulence factors of the mutans streptococci, including the cell-surface fibrillar proteins, which mediate adherence to the tooth surface, and the glucosyltransferase enzymes, which synthesise adhesive glucans and allow microbial accumulation on the teeth. Current strategies for immunisation against dental caries are using these virulence factors as key antigens and incorporating them into novel mucosalvaccine systems and delivering them with or without adjuvants to mucosal IgA inductive sites. The most popular routes of mucosal immunisation are viathe oral or nasal route, The mucosal immune system is functional in newborn infants, who develop salivary IgA antibodies as they become colonised by oral micro-organisms. Mucosal immunisation strategies result in the induction of salivary IgA antibody responses and pose fewer problems than parenteral injection of antigen. Therefore, mucosal immunisation of infants prior to the appearance of their first teeth may be a well tolerated and effectiveway to induce immunity against the colonisation of teeth by mutans streptococci and protection against subsequent dental caries. The purpose of this article is to provide an overview of the recent progress on the developmentof a vaccine against infection by Streptococcus mutans for the prevention of dental caries, with emphasis on the mucosal immune system and vaccine design.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:24:18