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Titolo:
Metabolism of vitamin A affected by prostaglandin F synthase in contractile interstitial cells of bovine lung
Autore:
Endo, K; Fukui, M; Mishima, M; Watanabe, K;
Indirizzi:
Univ E Asia, Grad Sch Integrated Sci & Art, Div Appl Life Sci, Yamaguchi 7518503, Japan Univ E Asia Yamaguchi Japan 7518503 l Life Sci, Yamaguchi 7518503, Japan Hyougo Prefectural Tsukaguchi Hosp, Dept Resp Dis, Amagasaki, Hyogo 6610012, Japan Hyougo Prefectural Tsukaguchi Hosp Amagasaki Hyogo Japan 6610012 2, Japan Kitano Hosp, Dept Resp Med, Kita Ku, Osaka 5308480, Japan Kitano Hosp Osaka Japan 5308480 Resp Med, Kita Ku, Osaka 5308480, Japan Kyoto Univ, Grad Sch Med, Dept Resp Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Resp Med, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 287, anno: 2001,
pagine: 956 - 961
SICI:
0006-291X(20011005)287:4<956:MOVAAB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY FIBROSIS; RETINOIC ACID; ACTIN ISOFORM; ITO CELLS; EXPRESSION; RAT; MYOFIBROBLASTS; BLEOMYCIN; LIVER; STORAGE;
Keywords:
vitamin A; prostaglandin F synthase; lung; contactile interstitial cells; aldo-keto reductase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, K Univ E Asia, Grad Sch Integrated Sci & Art, Div Appl Life Sci,2-1 Ichinomiya Gakuencho, Yamaguchi 7518503, Japan Univ E Asia 2-1 Ichinomiya Gakuencho Yamaguchi Japan 7518503
Citazione:
K. Endo et al., "Metabolism of vitamin A affected by prostaglandin F synthase in contractile interstitial cells of bovine lung", BIOC BIOP R, 287(4), 2001, pp. 956-961

Abstract

Contractile interstitial cells (CIC), the major component of the alveolar septum of the bovine lung are enriched in prostaglandin (PG) F synthase (Fukui, M., Fujimoto, T., Watanabe, K., Endo, K., and Kuno, K. (1996) J. Histochem. Cytochem 44, 251-257.). The enzyme catalyzes not only the reduction of PGD(2) and PGH(2) but also that of various carbonyl compounds (Watanabe, K., Yoshida, R., Shimizu, T., and Hayaishi, O. (1985) J. Biol Chem. 260, 7035-7041). Here, we report that retinal (vitamin A-aldehyde) was reduced to retinol (vitamin A-alcohol) dose- and time-dependently by PGF synthase using NADPH as a cofactor. The Km value of PGF synthase for retinal was about 20 muM, a same order to that for PGH(2). The conversion of retinal to retinol was also observed in cultured CIC, as demonstrated by the greenish fluorescence characteristic of retinol. Thus, retinal might be one of the naturalsubstrates for PGF synthase in vivo, and retinol synthesized from retinal in CIC may play physiological and pathological roles in the lungs. (C) 2001Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:10:38