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Titolo:
A new stroke marker as detected by serum phosphoglycerate mutase B-type isozyme
Autore:
Hayashi, T; Matuo, Y;
Indirizzi:
Oriental Yeast Co Ltd, Nagahama Inst Biochem Sci, Nanahama, Shiga 5260804,Japan Oriental Yeast Co Ltd Nanahama Shiga Japan 5260804 a, Shiga 5260804,Japan Osaka Med Coll, Osaka, Japan Osaka Med Coll Osaka JapanOsaka Med Coll, Osaka, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 287, anno: 2001,
pagine: 843 - 845
SICI:
0006-291X(20011005)287:4<843:ANSMAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
2,3-BISPHOSPHOGLYCERATE PHOSPHATASE; ISOENZYMES;
Keywords:
phosphoglycerate mutase; PGM; B-type isozyme; hypoxia; stroke; head trauma; myocardial infarction; diagnosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Hayashi, T Oriental Yeast Co Ltd, Nagahama Inst Biochem Sci, 50 Kano Cho, Nanahama, Shiga 5260804, Japan Oriental Yeast Co Ltd 50 Kano Cho Nanahama Shiga Japan 5260804
Citazione:
T. Hayashi e Y. Matuo, "A new stroke marker as detected by serum phosphoglycerate mutase B-type isozyme", BIOC BIOP R, 287(4), 2001, pp. 843-845

Abstract

The diagnostic significance of phosphoglycerate mutase (PGM) B-type isozyme activity capable of being inducible under hypoxia at the gene level as a serum marker for cerebral stroke was investigated. The normal level (mean +/- 2 SD) in human serum was determined to be 38 +/- 18 units/L. Within 2 h after the onset of cerebral stroke (n = 65), B-type isozyme activity was elevated to 68 +/- 36 units/L, and retained to be higher level until 1-3 days. Serum B-type isozyme activities of 52 survival cases and 13 dead cases, being judged at the period of 1-2 months after the onset, were retrospectively compared; B-type isozyme activity that had been measured within 24 h after the onset was significantly higher (81 +/- 42 units/L) for the dead cases than for survival cases (57 +/- 27 units/L) with P < 0.05. These results suggest that serum PGM B-type isozyme has the potential as a novel marker for diagnosis of cerebral stroke and its severity. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:01:17