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Titolo:
Cisplatin ototoxicity in the Sprague Dawley rat evaluated by distortion product otoacoustic emissions
Autore:
Hatzopoulos, S; Di Stefano, M; Campbell, KCM; Falgione, D; Ricci, D; Rosignoli, M; Finesso, M; Albertin, A; Previati, M; Capitani, S; Martini, A;
Indirizzi:
Univ Ferrara, Dept Audiol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 , Dept Audiol, I-44100 Ferrara, Italy Univ Ferrara, Ctr Bioacoust, I-44100 Ferrara, Italy Univ Ferrara FerraraItaly I-44100 Ctr Bioacoust, I-44100 Ferrara, Italy So Illinois Univ, Sch Med, Dept Surg, Springfield, IL USA So Illinois Univ Springfield IL USA Med, Dept Surg, Springfield, IL USA Univ Ferrara, Sect Gen Physiol, Dept Biol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 ol, Dept Biol, I-44100 Ferrara, Italy Univ Ferrara, Sect Human Anatomy, Dept Morphol & Embryol, Ferrara, Italy Univ Ferrara Ferrara Italy tomy, Dept Morphol & Embryol, Ferrara, Italy Fidia Res Labs, Padua, Italy Fidia Res Labs Padua ItalyFidia Res Labs, Padua, Italy
Titolo Testata:
AUDIOLOGY
fascicolo: 5, volume: 40, anno: 2001,
pagine: 253 - 264
SICI:
0020-6091(200109/10)40:5<253:COITSD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALBINO GUINEA-PIGS; HAIR CELL LOSS; ACOUSTIC DISTORTION; IMPAIRED EARS; ANIMAL-MODEL; CIS-PLATINUM; HEARING-LOSS; INNER-EAR; COCHLEA; VULNERABILITY;
Keywords:
distortion product otoacoustic emissions; cisplatin; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hatzopoulos, S Univ Ferrara, Dept Audiol, 203 Corso Giovecca, I-44100 Ferrara, Italy Univ Ferrara 203 Corso Giovecca Ferrara Italy I-44100 taly
Citazione:
S. Hatzopoulos et al., "Cisplatin ototoxicity in the Sprague Dawley rat evaluated by distortion product otoacoustic emissions", AUDIOLOGY, 40(5), 2001, pp. 253-264

Abstract

The present study has evaluated the use of distortion product otoacoustic emission (DPOAE) responses in the detection of cisplatin-induced ototoxicity in a Sprague Dawley rat animal model, The cisplatin was administered as a16 mg/kg, dose introduced by a slow 50-min intraperitoneal infusion. Data from three DP-gram protocols, DPOAE input-output responses at 8 kHz, and auditory brainstem responses (ABRs) at 8, 12 and 16 kHz were collected beforeand 72 h after treatment. The post-treatment ABRs at 16 kHz showed the greatest mean threshold shift of 33.6 dB. The post-treatment DP-gram data showed significant reduction of the signal to noise ratios in the majority of the frequencies tested, across aft tested protocols. The data suggest that the most sensitive DPOAE procedure for the early detection of the cisplatin-induced ototoxic damage is the DPOAE I/O protocol. Morphological analyses indicated that the inner hair cells remained intact, while several types of alterations were observed in the arrangement of the stereocilia in the outer hair cells.

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Documento generato il 09/04/20 alle ore 10:54:43