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Titolo:
Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage
Autore:
Dansky, HM; Barlow, CB; Lominska, C; Sikes, JL; Kao, C; Weinsaft, J; Cybulsky, MI; Smith, JD;
Indirizzi:
Rockefeller Univ, New York, NY 10021 USA Rockefeller Univ New York NY USA10021 eller Univ, New York, NY 10021 USA Univ Toronto, Toronto Gen Res Inst, Toronto, ON, Canada Univ Toronto Toronto ON Canada Toronto Gen Res Inst, Toronto, ON, Canada
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 10, volume: 21, anno: 2001,
pagine: 1662 - 1667
SICI:
1079-5642(200110)21:10<1662:AOMTAE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-DEFICIENT MICE; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E; P-SELECTIN; LESION FORMATION; EXPRESSION; MOUSE; VCAM-1; ABSENCE; RABBIT;
Keywords:
vascular cell adhesion molecule-1; apolipoprotein E; hypercholesterolemia; gene targeting; monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, JD Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 Y 10021 USA
Citazione:
H.M. Dansky et al., "Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage", ART THROM V, 21(10), 2001, pp. 1662-1667

Abstract

Vascular cell adhesion molecule-1 (VCAM-1/Vcam1) is a cytokine-inducible member of the immunoglobulin gene superfamily that is expressed by arterial endothelial cells in regions predisposed to atherosclerosis and at borders of atherosclerotic plaques. To determine whether VCAM-1 expression regulates atherosclerotic lesion formation, we crossed Vcam1 domain 4-deficient (D4D) mice, which partially circumvent the embryonic lethality of Vcam1 null mice, with apolipoprotein E null (Apoe(-/-)) mice, which spontaneously develop hypercholesterolemia and atherosclerosis. In the Apoe(-/-) background, mice homozygous for the Vcam1 D4D allele had markedly reduced arterial VCAM-1 expression, monocyte adherence in the aortic root, and fatty streak formation, Heterozygous Vcam1 D4D mice revealed a Vcam1 gene-dosage effect and had intermediate, yet significant, reductions in these parameters. Our data demonstrate that VCAM-1 plays a pivotal role in the initiation of atherosclerosis in Apoc(-/-) mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:03:07