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Titolo:
Markedly elevated lipid transfer inhibitor protein in hypercholesterolemicsubjects is mitigated by plasma triglyceride levels
Autore:
Morton, RE; Nunes, V; Izem, L; Quintao, E;
Indirizzi:
Cleveland Clin Fdn, Dept Cell Biol, Lerner Inst, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 r Inst, Cleveland, OH 44195 USA Univ Sao Paulo, Sch Med, Lipids Lab, Sao Paulo, Brazil Univ Sao Paulo SaoPaulo Brazil Sch Med, Lipids Lab, Sao Paulo, Brazil
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 10, volume: 21, anno: 2001,
pagine: 1642 - 1649
SICI:
1079-5642(200110)21:10<1642:MELTIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTERYL ESTER TRANSFER; LIPOPROTEIN-DEFICIENT PLASMA; CACO-2 CELLS; SECRETION; PURIFICATION; MODEL;
Keywords:
hypercholesterolemia; cholesteryl ester transfer protein; lipid transfer inhibitor protein; triglycerides; lipoprotein metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Morton, RE Cleveland Clin Fdn, Dept Cell Biol, Lerner Inst, NC10,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn NC10,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
R.E. Morton et al., "Markedly elevated lipid transfer inhibitor protein in hypercholesterolemicsubjects is mitigated by plasma triglyceride levels", ART THROM V, 21(10), 2001, pp. 1642-1649

Abstract

Lipid transfer inhibitor protein (LTIP, apolipoprotein F) regulates the interaction of cholesteryl ester transfer protein (CETP) with lipoproteins and is postulated to enhance the ability of CETP to stimulate reverse cholesterol transport. The factors that regulate LTIP levels and control its biosynthesis are unknown. Here, we demonstrate that plasma LTIP is dramatically increased (3-fold) in hypercholesterolemic subjects with normal to mildly elevated plasma triglyceride (TG) levels compared with control subjects. LTIP in these subjects is not correlated with the extent of hypercholesterolemia or with low density lipoprotein (LDL), high density lipoprotein, or CETPlevels. However, unlike CETP, LTIP levels correlate negatively with plasmaTG levels. This association does not appear to reflect decreased LTIP synthesis, inasmuch as conditions that stimulate TG synthesis and secretion (200 mu mol/L oleate) do not reduce LTIP secretion by SW872 or Caco-2 cells. In contrast, native or acetyl LDL stimulates LTIP secretion 2-fold. Importantly, although plasma LTIP typically resides on LDL, up to 25% of LTIP is bound to very low density lipoprotein when this lipoprotein is enriched in cholesteryl esters, as occurs in hypercholesterolemia. In summary, LTIP levels are markedly elevated by hypercholesterolemia; however, plasma TG levels attenuate this response. We hypothesize that this arises from an increased association of LTIP with very low density lipoprotein, leading to a more rapid clearance of the inhibitor from circulation.

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Documento generato il 31/05/20 alle ore 13:21:43