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Titolo:
Relationship of clinical presentation and calcification of culprit coronary artery stenoses
Autore:
Beckman, JA; Ganz, J; Creager, MA; Ganz, P; Kinlay, S;
Indirizzi:
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Div Cardiovasc, Boston, MA 02115 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 10, volume: 21, anno: 2001,
pagine: 1618 - 1622
SICI:
1079-5642(200110)21:10<1618:ROCPAC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEAM COMPUTED-TOMOGRAPHY; INTRAVASCULAR ULTRASOUND; MYOCARDIAL-INFARCTION; ATHEROSCLEROTIC PLAQUES; INTRACORONARY ULTRASOUND; RISK-FACTORS; CALCIUM; DISEASE; PROGRESSION; MORPHOLOGY;
Keywords:
calcinosis; calcium; coronary vessels; ultrasonography, interventional; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Beckman, JA Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA Harvard Univ 75 Francis St Boston MA USA 02115 n, MA 02115 USA
Citazione:
J.A. Beckman et al., "Relationship of clinical presentation and calcification of culprit coronary artery stenoses", ART THROM V, 21(10), 2001, pp. 1618-1622

Abstract

Coronary artery calcification is increased in the presence of atherosclerosis. However, there is great variability in the calcification of individualcoronary stenoses, and the clinical significance of this finding remains unknown. We tested the hypothesis that culprit lesions associated with myocardial infarction or unstable angina are less calcified than are stenoses associated with stable angina. The study consisted of 78 patients who underwent intravascular ultrasound imaging of culprit stenoses after the placementof a stent. Seventeen patients presented with stable angina; 43, with unstable angina; and 18, with myocardial infarction. The extent of coronary calcification was measured by the angle of its are and was quantified with a computer-based protractor. The are of calcium was measured in the stented area at the point of maximal calcification and also as an average of the calcification found at proximal, middle, and distal stent segments. The maximalarc of calcium decreased progressively from patients with stable angina (91 +/- 10 degrees) to those with unstable angina (59 +/-8 degrees) and to those with myocardial infarction (49 +/- 11 degrees, P=0.014). Similarly, theaverage arc of calcium was greatest (32 +/-7 degrees) in patients with stable angina, less (15 +/-4 degrees) in patients with unstable angina, and least (10 +/-5 degrees) in patients with acute myocardial infarction (P=0.014). These associations remained significant after adjustment for other factors that potentially affect arterial calcification. Acute coronary syndromesare associated with a relative lack of calcium in the culprit stenoses compared with stenoses of patients with stable angina. These findings have implications for the understanding of the biology of acute coronary syndromes as well as for the identification of coronary stenoses by methods that relysolely on the presence of calcium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:44:23