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Titolo:
PROLONGED INTESTINAL AFFERENT NERVE DISCHARGE IN RESPONSE TO CHOLECYSTOKININ-58 COMPARED TO CHOLECYSTOKININ-8 IN RATS
Autore:
KREIS ME; ZITTEL TT; RAYBOULD HE; REEVE JR; GRUNDY D;
Indirizzi:
UNIV TUBINGEN HOSP,DEPT GEN SURG TUBINGEN GERMANY UNIV TUBINGEN HOSP,DEPT GEN SURG TUBINGEN GERMANY UNIV CALIF LOS ANGELES,CTR ULCER RES & EDUC,GASTROENTER BIOL CTR LOS ANGELES CA 90024 UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 230, anno: 1997,
pagine: 89 - 92
SICI:
0304-3940(1997)230:2<89:PIANDI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-FORMS; DOGS; RELEASE;
Keywords:
AFFERENT NERVE; CHOLECYSTOKININ-8; CHOLECYSTOKININ-58; CHOLECYSTOKININ PHYSIOLOGY; EXTRINSIC INNERVATION; SMALL INTESTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Kreis et al., "PROLONGED INTESTINAL AFFERENT NERVE DISCHARGE IN RESPONSE TO CHOLECYSTOKININ-58 COMPARED TO CHOLECYSTOKININ-8 IN RATS", Neuroscience letters, 230(2), 1997, pp. 89-92

Abstract

Intestinal afferents are sensitive to cholecystokinin (CCK) octapeptide. However, CCK-58 may be a more biologically relevant molecule. Therefore, recordings from jejunal mesenteric afferent bundles were secured for extracellular multi-unit recording and the responses to CCK-8 and CCK-58 compared. CCK-8 and CCK-58 (i.v.) evoked a dose-dependent, devazepide sensitive, increase in afferent nerve discharge, Peak discharge frequency was higher for CCK-8 at all doses (P < 0.05). However, response duration was more prolonged for CCK-58 (P < 0.05) at 200 pmol.kg(-1). This resulted in an overall increase in area under the curve ofCCK-58 compared to CCK-8 (P < 0.05). CCK-58 stimulates afferent discharge in a different pattern than CCK-8 and, therefore, may have differential biological effects. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:06:29