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Titolo:
Severe staphylococcal pneumonia in children
Autore:
Gillet, Y; Issartel, B; Vanhems, P; Lina, G; Vandenesch, F; Etienne, J; Floret, D;
Indirizzi:
Hop Edouard Herriot, Serv Urgences & Reanimat Pediat, F-69437 Lyon, FranceHop Edouard Herriot Lyon France F-69437 mat Pediat, F-69437 Lyon, France Fac Med RTH Laennec, Ctr Natl Reference Toxemies Staphylocoques, EA1655, Lyon, France Fac Med RTH Laennec Lyon France es Staphylocoques, EA1655, Lyon, France Hop Edouard Herriot, Unite Hyg Hosp, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 e Hyg Hosp, F-69437 Lyon, France
Titolo Testata:
ARCHIVES DE PEDIATRIE
, volume: 8, anno: 2001, supplemento:, 4
pagine: 742S - 746S
SICI:
0929-693X(200109)8:<742S:SSPIC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
FRE
Soggetto:
AUREUS; LEUKOCIDIN;
Keywords:
child; staphylococcal; pneumonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Gillet, Y Hop Edouard Herriot, Serv Urgences & Reanimat Pediat, 5 Pl Arsonval, F-69437 Lyon, France Hop Edouard Herriot 5 Pl Arsonval Lyon France F-69437 n, France
Citazione:
Y. Gillet et al., "Severe staphylococcal pneumonia in children", ARCH PED, 8, 2001, pp. 742S-746S

Abstract

Between 1986 and 1999, 8 cases of severe pneumonia due Staphylococcus aureus strains producing the Panton and Valentine leucotoxin (PVL) were referred to the French reference centre for staphylococcal toxaemia. All but one patient were children and to determine the clinical features of these pneumonia we conducted a prospective surveillance during 1999. Staphylococcal pneumonia was defined according to usual standards. All the strains were tested for the gene coding PVL, the cases associated with PVL positive strains were considered as study group. Nosocomial pneumonia were excluded. 52 caseswere referred and 16 were PVL positive. These pneumonia occurred in younger patients (median age = 14.8 vs. 70.1) which were previously healthy (40% of underlying disease in control) Remarkable features were the presence of viral infection in the preceding day (75% vs. 9%), the frequency of shock (81% vs. 53%), respiratory distress (75% vs. 53%) and hemoptysia (38% vs. 3%). Leucopenia was present in 79% of cases. Mortality was higher in the PVL group (75% vs. 47%). Severe staphylococcal pneumonia with shock, leucopenia, hemoptysia and high mortality rate have been previously described in children and young adults. We established the relationship between this syndromand the PVL production by S. aureus. We believe that viral infection constitue the prerequisite altering the respiratory epithelium which secondary allows S. aureus invasion. The necrotizing action of the PVL leads to the massive haemorragic necrotic pneumonia. Staphyloccocal necrotizing pneumonia is a new entity which frequency is probably underestimated. Further studiesare needed to determinate the prognosis factors, the role of S. aureus carriage and of viral infections. The description of this new syndrome could lead to changes in the management of staphylococcal pneumonia in children. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:33:35