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Titolo:
Mechanisms of tamoxifen-induced apoptosis
Autore:
Mandlekar, S; Kong, ANT;
Indirizzi:
Dupont Pharmaceut Co, Dept Drug Metab & Pharmacokinet, Newark, DE 19711 USA Dupont Pharmaceut Co Newark DE USA 19711 rmacokinet, Newark, DE 19711 USA Rutgers State Univ, Coll Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 ceut, Piscataway, NJ 08854 USA Rutgers State Univ, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854USA Rutgers State Univ Piscataway NJ USA 08854 Inst, Piscataway, NJ 08854USA
Titolo Testata:
APOPTOSIS
fascicolo: 6, volume: 6, anno: 2001,
pagine: 469 - 477
SICI:
1360-8185(200112)6:6<469:MOTA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER-CELLS; PROTEIN-KINASE-C; MYC-INDUCED APOPTOSIS; MITOCHONDRIAL PERMEABILITY TRANSITION; GROWTH-FACTOR-BETA; N-TERMINAL KINASE; CHEMOTHERAPY-INDUCED APOPTOSIS; CARCINOMA CELLS; CYTOCHROME-C; SIGNAL-TRANSDUCTION;
Keywords:
apoptosis; breast cancer; caspases; signal transduction; tamoxifen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Mandlekar, S Dupont Pharmaceut Co, Dept Drug Metab & Pharmacokinet, 1094 Elkton Rd, Newark, DE 19711 USA Dupont Pharmaceut Co 1094 Elkton Rd Newark DE USA 19711 1 USA
Citazione:
S. Mandlekar e A.N.T. Kong, "Mechanisms of tamoxifen-induced apoptosis", APOPTOSIS, 6(6), 2001, pp. 469-477

Abstract

Tamoxifen (TAM) has been used in the treatment of breast cancer for over adecade. The observed clinical efficacy of TAM has been attributed to both growth arrest and induction of apoptosis within the breast cancer cells. Although the primary mechanism of action of TAM is believed to be through theinhibition of estrogen receptor (ER), research over the years has indicated that additional, non-ER-mediated mechanisms exist. These include modulation of signaling proteins such as protein kinase C (PKC), calmodulin, transforming growth factor-beta (TGF beta), and the protooncogene c-myc. Recent studies, including those from our laboratory, have implicated the role of caspases and mitogen-activated protein kinases (MAPK), including c-Jun N-terminal kinase (JNK) and p38 in TAM-induced apoptotic signaling. Oxidative stress, mitochondrial permeability transition (MPT), ceramide generation as well as changes in cell membrane fluidity may also play important roles in TAM-induced apoptosis. These various signaling pathways underlying TAM-induced apoptosis will be reviewed in this article.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:22:35