Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1
Autore:
Forch, P; Valcarcel, J;
Indirizzi:
European Mol Biol Lab, Prot Design Grp, Gene Express Programme, D-69117 Heidelberg, Germany European Mol Biol Lab Heidelberg Germany D-69117 117 Heidelberg, Germany
Titolo Testata:
APOPTOSIS
fascicolo: 6, volume: 6, anno: 2001,
pagine: 463 - 468
SICI:
1360-8185(200112)6:6<463:MMOGER>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-BINDING PROTEIN; RECEPTOR-2 ALTERNATIVE EXON; CHICKEN-EMBRYO FIBROBLASTS; GROWTH-FACTOR RECEPTORS; FAS-MEDIATED APOPTOSIS; TUMOR-NECROSIS-FACTOR; MESSENGER-RNA; INTRON SEQUENCES; STRESS GRANULES; CELL-DEATH;
Keywords:
mechanisms; post-transcriptional regulation; TIA-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Valcarcel, J European Mol Biol Lab, Prot Design Grp, Gene Express Programme, Meyerhofstr 1, D-69117 Heidelberg, Germany European Mol Biol Lab Meyerhofstr 1 Heidelberg Germany D-69117
Citazione:
P. Forch e J. Valcarcel, "Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1", APOPTOSIS, 6(6), 2001, pp. 463-468

Abstract

TIA-1 and the related protein TIAR promote DNA fragmentation in digitonin-permeabilized thymocytes. These proteins contain RNA Recognition Motifs (RRMs) and bind uridine-rich sequences. These observations suggested that TIA-1/TIAR are pro-apoptotic factors that influence some aspect of RNA metabolism. Here we review recent data implicating TIA-1 as a regulator of translation of Tumor Necrosis Factor-alpha mRNA and as regulator of alternative splicing of a variety of pre-mRNAs, including those of the Fibroblast Growth Factor Receptor 2 and the Fas receptor. We also discuss how some of these activities could be integrated in the control of programmed of cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:04:09