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Titolo:
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis
Autore:
Liu, D; Huang, Z;
Indirizzi:
Univ Illinois, Dept Biochem, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Dept Biochem, Urbana, IL 61801 USA
Titolo Testata:
APOPTOSIS
fascicolo: 6, volume: 6, anno: 2001,
pagine: 453 - 462
SICI:
1360-8185(200112)6:6<453:SPANMA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; CYTOCHROME-C RELEASE; ION-CHANNEL; ISOLATED-MITOCHONDRIA; ANTIAPOPTOTIC BCL-2; ANTISENSE THERAPY; TERMINAL DOMAIN; TUMOR-CELLS; BH4 DOMAIN; KINASE-C;
Keywords:
apoptosis; Bcl-2 family; cancer; caspases; drug design; mitochondria; peptides; structure and function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, Z Univ Illinois, Dept Biochem, 302 Burrill Hall,MC-119,407 S Goodwin Ave, Urbana, IL 61801 USA Univ Illinois 302 Burrill Hall,MC-119,407 S Goodwin Ave Urbana IL USA 61801
Citazione:
D. Liu e Z. Huang, "Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis", APOPTOSIS, 6(6), 2001, pp. 453-462

Abstract

The Bcl-2 family includes a growing number of proteins that play an essential role in regulating apoptosis or programmed cell death. Members of this family display diverse biological functions and can either inhibit or promote cell death signals. Abnormal gene expression of some Bcl-2 family members such as Bcl-2 that inhibits apoptosis is found in a wide variety of humancancers and contributes to the resistance of tumor cells to conventional therapies through interfering with the cell death signals triggered by chemotherapeutic agents. As such, elucidating the structure-function and mechanism of the Bcl-2 family is important for understanding some of the fundamental principles underling the death and survival of cells and of practical value for developing potential therapeutics to control apoptosis in pathological processes. Synthetic peptides derived from homologous or heterogeneous domains in Bcl-2 family proteins that might mediate different biological activities provide simplified and experimentally more tractable models as compared to their full-length counterparts to dissect and analyze the complex functional roles of these proteins. Non-peptidic molecules identified from random screening of natural products or designed by rational structure-based techniques can mimic the effect of synthetic peptides by targeting similar active sites on a Bcl-2 family member protein. In this article, we reviewrecent progress in using these synthetic peptides and non-peptidic mimic molecules to obtain information about the structure and function of Bcl-2 family proteins and discuss their application in modulating and studying intracellular apoptotic signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:57:34