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Titolo:
p73 in apoptosis
Autore:
Stiewe, T; Putzer, BM;
Indirizzi:
Univ Essen Gesamthsch, Sch Med, Inst Mol Biol, Ctr Canc Res & Canc Therapy, D-45122 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45122 rapy, D-45122 Essen, Germany
Titolo Testata:
APOPTOSIS
fascicolo: 6, volume: 6, anno: 2001,
pagine: 447 - 452
SICI:
1360-8185(200112)6:6<447:PIA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 HOMOLOG P73; KINASE C-ABL; TUMOR-SUPPRESSOR; DNA-DAMAGE; TYROSINE KINASE; CELL-LINES; P53-RELATED PROTEIN; SPLICE VARIANTS; TERMINAL DOMAIN; HUMAN CANCERS;
Keywords:
apoptosis; p73; tumour suppressor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Putzer, BM Univ Essen Gesamthsch, Sch Med, Inst Mol Biol, Ctr Canc Res & Canc Therapy, Hufelandstr 55, D-45122 Essen, Germany Univ Essen Gesamthsch Hufelandstr 55 Essen Germany D-45122 any
Citazione:
T. Stiewe e B.M. Putzer, "p73 in apoptosis", APOPTOSIS, 6(6), 2001, pp. 447-452

Abstract

The TP53 tumour-suppressor gene belongs to a family that includes the two recently identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53-responsive genes and induce apoptosis like p53. In addition, activation of p73 has been implicated in apoptotic cell death induced by aberrant cell proliferation and some forms of DNA-damage. These data together with the localization of TP73 on chromosome 1p36, a region frequently deleted in a variety of human cancers, led to the hypothesis that p73 has tumour suppressor activity just like p53. However, despite its proapoptotic activity in vitro, the lack of tumour-formation in p73 knock-out mice and primary human tumour data demonstrating overexpression of wild-type p73 currently argue against p73 being a classical tumour suppressor. Interestingly,in contrast to TP53, TP73 gives rise to a complex pattern of pro- and antiapoptotic p73 isoforms generated by differential splicing and alternative promoter usage. Therefore further insight into the function and regulation of these structurally and functionally diverse p73 proteins is needed to elucidate the role of TP73 for apoptosis and human tumorigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:05:28