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Titolo:
Antiplatelet agents for secondary prevention of ischemic stroke
Autore:
Majid, A; Delanty, N; Kantor, J;
Indirizzi:
Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA Beaumont Hosp, Royal Coll Surg, Dept Neurol, Dublin 9, Ireland Beaumont Hosp Dublin Ireland 9 Coll Surg, Dept Neurol, Dublin 9, Ireland Univ Penn, Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Biostat, Philadelphia, PA 19104 USA
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 10, volume: 35, anno: 2001,
pagine: 1241 - 1247
SICI:
1060-0280(200110)35:10<1241:AAFSPO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBOTIC THROMBOCYTOPENIC PURPURA; AMERICAN-HEART-ASSOCIATION; COST-EFFECTIVENESS ANALYSIS; STABLE ANGINA-PECTORIS; ASPIRIN; DIPYRIDAMOLE; TICLOPIDINE; CLOPIDOGREL; MANAGEMENT; RECURRENCE;
Keywords:
antiplatelets; aspirin; clopidogrel; dipyridamole; stroke; ticlopidine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Majid, A Presbyterian Hosp, Dept Transit Med, 266 Wright Saunders, Philadelphia, PA19104 USA Presbyterian Hosp 266 Wright Saunders Philadelphia PA USA 19104 A
Citazione:
A. Majid et al., "Antiplatelet agents for secondary prevention of ischemic stroke", ANN PHARMAC, 35(10), 2001, pp. 1241-1247

Abstract

OBJECTIVE, To review and summarize the efficacy, mechanisms of action, andcost of the options available when choosing antiplatelet agents for secondary stroke prevention. DATA SOURCES: This article is based on a review of the literature found with MEDLINE, CINAHL, and Cochrane Reviews (1980-June 2000) and abstracts from relevant international scientific meetings. We searched for the terms aspirin, ticlopidine, dipyridamole, antiplatelet, and clopidogrel. STUDY SELECTION: English-language articles, both reviews and original studies, were evaluated, and all information considered relevant was included in this review. In addition, guidelines from the American Heart Association are Included. DATA SYNTHESIS; Aspirin is a relatively inexpensive and effective agent fbr secondary stroke prevention, and lower doses of aspirin appear as effective as higher doses. Ticlopidine has been used alone or in combination with aspirin, but serious adverse effects have limited its use. Clopidogrel has emerged as a safe and effective alternative to ticlopidine and lacks some of the serious adverse effects associated with ticlopidine, but is not superior to aspirin in secondary stroke prevention. Unlike previous studies, onerecent trial showed that dipyridamole in combination with aspirin is superior to aspirin alone. CONCLUSIONS: Antiplatelet therapy is a key component of secondary prevention strategies in ischemic stroke. While aspirin has been the cornerstone inthe management of stroke, other classes of antiplatelet drugs present new opportunities to optimize antiplatelet therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:24:22