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Titolo:
Effects of heparin on hypertonic potassium chloride-induced bronchoconstriction
Autore:
Tutluoglu, B; Gurbuz, N; Atis, S; Abanozlu, S; Ibis, R; Kanik, A;
Indirizzi:
Kartal Educ & Res Hosp, Dept Chest Dis, Istanbul, Turkey Kartal Educ & ResHosp Istanbul Turkey Dept Chest Dis, Istanbul, Turkey Mersin Univ, Dept Chest Dis, Fac Med, Mersin, Turkey Mersin Univ Mersin Turkey Univ, Dept Chest Dis, Fac Med, Mersin, Turkey Bursa Chest Dis Hosp, Bursa, Turkey Bursa Chest Dis Hosp Bursa TurkeyBursa Chest Dis Hosp, Bursa, Turkey Kartel Educ & Res Hosp, Dept Internal Med, Istanbul, Turkey Kartel Educ & Res Hosp Istanbul Turkey t Internal Med, Istanbul, Turkey Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey Mersin Univ Mersin Turkey n Univ, Fac Med, Dept Biostat, Mersin, Turkey Univ Istanbul, Dept Chest Dis, Cerrahpasa Fac Med, Istanbul, Turkey Univ Istanbul Istanbul Turkey Dis, Cerrahpasa Fac Med, Istanbul, Turkey
Titolo Testata:
ANNALS OF PHARMACOTHERAPY
fascicolo: 10, volume: 35, anno: 2001,
pagine: 1161 - 1165
SICI:
1060-0280(200110)35:10<1161:EOHOHP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; INHALED HEPARIN; TIME-COURSE; HUMAN-LUNG; HYPERRESPONSIVENESS; METHACHOLINE; RESPONSES; CHALLENGE; ANTIGEN; SALINE;
Keywords:
bronchial asthma; heparin; hypertonic potassium chloride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Tutluoglu, B Hasircibasi Cad Arutan Apt 65-14, TR-81300 Istanbul, Turkey Hasircibasi Cad Arutan Apt 65-14 Istanbul Turkey TR-81300 y
Citazione:
B. Tutluoglu et al., "Effects of heparin on hypertonic potassium chloride-induced bronchoconstriction", ANN PHARMAC, 35(10), 2001, pp. 1161-1165

Abstract

BACKGROUND: Changes in bronchial osmolarity Is a well-known factor for bronchoconstriction. Recently, nonisotonic aerosols have begun to be used for the assessment of bronchial hyperreactivity. Hypertonic KCl can cause bronchoconstriction even in nonsymptomatic asthmatic patents. OBJECTIVE To evaluate the protective rule of heparin on hypertonic KCI-induced bronchospasm in asthma. METHODS: Thirty-eight asthmatic patients were included in this double-blind, placebo-controlled study. On day 1 of the study, after performing the respiratory function test (RFT), patents had inhaled KCl 10% and RFTs; were done after 20 minutes. On day 2 of the study, after the basal RFT, 18 patients inhaled NaCl 0.90% 0.2 mL/kg solution. After the completion of this procedure, patients waited for 20 minutes and inhaled KCI 10% 10 mL, and RFTs were repeated 20 minutes later. The second group consisted of 20 patients who inhaled heparin 1000 units/kg after the RFTs; were performed. Twenty minutes later, they inhaled KCI 10% and wafted for 20 minutes. Finally, RFTs were done and compared with those from the other group. RESULTS: In the control group, forced expiratory volume in one second (FEV,) decreased 17.4% on day 1 and 16.41% on day 2. In the heparin-treated group, FEV1 decreased 18.6% on day 1, but almost no change occurred after thisgroup was treated with heparin before Inhalation of hypertonic KCl on day 2. CONCLUSIONS: Heparin was found to be highly protective against hypertonic KCl-induced bronchospasm in bronchial asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:24:54