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Titolo:
Separate assessment of forearm cortical and trabecular bone density from standard densitometry data
Autore:
Boyanov, MA; Popivanov, PR; Roux, C;
Indirizzi:
Med Univ Sofia, Alexandrovs Hosp, Endocrinol Clin, BG-1431 Sofia, BulgariaMed Univ Sofia Sofia Bulgaria BG-1431 inol Clin, BG-1431 Sofia, Bulgaria Hop Cochin, Dept Rheumatol, Bone Unit, F-75674 Paris, France Hop Cochin Paris France F-75674 umatol, Bone Unit, F-75674 Paris, France
Titolo Testata:
ANNALS OF MEDICINE
fascicolo: 7, volume: 33, anno: 2001,
pagine: 497 - 506
SICI:
0785-3890(200110)33:7<497:SAOFCA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; X-RAY ABSORPTIOMETRY; MINERAL DENSITY; DISTAL FOREARM; PHOTON ABSORPTIOMETRY; HEALTHY-CHILDREN; SINGLE-PHOTON; WOMEN; RADIUS; MASS;
Keywords:
age-related changes; cortical bone density; forearm bone densitometry; trabecular bone density;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Boyanov, MA Med Univ Sofia, Alexandrovs Hosp, Endocrinol Clin, 1 St G Sofiiski Str, BG-1431 Sofia, Bulgaria Med Univ Sofia 1 St G Sofiiski Str SofiaBulgaria BG-1431 ria
Citazione:
M.A. Boyanov et al., "Separate assessment of forearm cortical and trabecular bone density from standard densitometry data", ANN MED, 33(7), 2001, pp. 497-506

Abstract

BACKGROUND. Cortical and trabecular bone are different bone components. Their mineral density cannot be measured directly by areal bone densitometry. AIM. To introduce a method for assessment of pure radial cortical and trabecular bone density based on standard densitometry data. METHOD. The study included 418 healthy females (aged 20-83 years, body mass index between 19 and 30) free of previous fractures and conditions or drugs affecting bone metabolism; as well as a group of 64 age-matched females with early menopause. Forearm bone density was measured by single X-ray absorptiometry and calculated separately for cortical and trabecular bone. Age-adjusted bone density curves were built. RESULTS. Peak bone density was found to occur between 30 and 34 years of age and was 0.561 g/cm(2) for cortical and 0.281 g/cm(2) for trabecular bone. In comparison, lowest values were registered between 70 and 74 years of age, cortical bone density reduced by 26% and trabecular density by 44%. Both bone density profiles through life reflected the earlier peri- and postmenopausal (mainly trabecular) and later senile (cortical bone also involved)changes in bone mass. A step-wise pattern of trabecular bone reduction wasregistered with acceleration around 45, 55 and 65 years. The effects of early menopause on trabecular and cortical bone were tested in the prematurely menopausal women. CONCLUSIONS. The ability of our model to discriminate between natural and premature menopause was moderate. Although hypothetical (based on calculations from integral densitometry data rather than on direct measurements), our method could differentiate between cortical and trabecular osteopenia andmay prove helpful in assessing the type of osteoporosis, in making therapychoices and monitoring response to therapy based on forearm bone density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:27:54