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Titolo:
Biochemical risk factors for cardiovascular disease in an aged male population: Emerging vascular pathogens
Autore:
Lippi, G; Arosio, E; Prior, M; Guidi, G;
Indirizzi:
Univ Verona, Ist Chim & Microscopia Clin, Dipartimento Sci Biomed & Morfol, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 Biomed & Morfol, I-37100 Verona, Italy Ctr Osped Clinicizzato, Ctr Riabilitaz Cardiovasc, Valeggio Sul Mincio, VR, Italy Ctr Osped Clinicizzato Valeggio Sul Mincio VR Italy ul Mincio, VR, Italy
Titolo Testata:
ANGIOLOGY
fascicolo: 10, volume: 52, anno: 2001,
pagine: 681 - 687
SICI:
0003-3197(200110)52:10<681:BRFFCD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-HEART-DISEASE; ENDOTHELIUM-DEPENDENT DILATION; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE CELLS; LIPID-LEVELS; TASK-FORCE; HOMOCYSTEINE; APOLIPOPROTEIN(A); ATHEROSCLEROSIS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Guidi, G Osped Policlin, Ist Chim & Microscopia Clin, Via Menegone 10, I-37100 Verona, Italy Osped Policlin Via Menegone 10 Verona Italy I-37100 erona, Italy
Citazione:
G. Lippi et al., "Biochemical risk factors for cardiovascular disease in an aged male population: Emerging vascular pathogens", ANGIOLOGY, 52(10), 2001, pp. 681-687

Abstract

The progressive increase of deaths and morbidity from cardiovascular disease (CVD) in most developed societies has led to the formulation of preventive strategies and application of several diagnostic guidelines. However, there is emerging evidence that most panels and algorithms are inadequate andrequire urgent revision and updating. Therefore, the aim of this study wasthe evaluation of a wide cardiovascular risk profile in elderly male patients with acute myocardial infarction (AMI) or peripheral occlusive disease (POD). The risk profile was assessed by measuring conventional serum lipid and lipoprotein levels and emerging parameters: lipoprotein(a) (Lp[a]), homocysteine (Hcy), and C-reactive protein (CRP). The concentration of triglycerides, Lp(a), Hcy and the total cholesterol/high-density lipoprotein (TC/HDL) ratio were significantly higher in both classes of patients than in a population of matched healthy controls and, similarly, patients with CVD displayed lower plasma values of HDL. No significant differences were observed for TC, low-density lipoprotein (LDL), and CRP, Patients with POD exhibited a marked atherogenic profile, as attested bysubstantially increased values of Hcy, Lp(a), triglycerides, and TC/HDL ratio. The frequency distributions of Lp(a) and Hcy concentrations were markedly shifted toward upper values in both classes of patients than in controls. In multivariate regression analysis, Lp(a) and Hcy were the best predictors for AMI, whereas Lp(a), Hcy, and the TC/HDL ratio were the best predictors for POD. Taken together, these data suggest that Lp(a) and Hcy excessesmight exert a central role in the development of atherosclerotic disease in elderly male patients. Thereby, the inclusion of those tests, along with the TC/HDL ratio and other more conventional analyses in panels for the evaluation of the cardiovascular risk might be profitable in terms of effectual prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:07:12