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Titolo:
Reduced red cell 2,3-diphosphoglycerate concentrations in critical illnesswithout decreased in vivo P50
Autore:
Morgan, TJ; Koch, D; Morris, D; Clague, A; Purdie, DM;
Indirizzi:
Royal Brisbane Hosp, Intens Care Facil, Div Anaesthesiol & Intens Care, Brisbane, Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 bane, Qld 4029, Australia Royal Brisbane Hosp, Intens Care Facil, Div Chem Pathol, Brisbane, Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 bane, Qld 4029, Australia
Titolo Testata:
ANAESTHESIA AND INTENSIVE CARE
fascicolo: 5, volume: 29, anno: 2001,
pagine: 479 - 483
SICI:
0310-057X(200110)29:5<479:RRC2CI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMOGLOBIN-OXYGEN AFFINITY; OXYHEMOGLOBIN DISSOCIATION CURVE; RESPIRATORY-DISTRESS SYNDROME; DISEASE; MECHANISMS; DELIVERY; MUSCLE;
Keywords:
critical care : acidaemia, 2,3-DPG; in vivo P50, standard P50;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, TJ Royal Brisbane Hosp, Intens Care Facil, Div Anaesthesiol & Intens Care, Brisbane, Qld 4029, Australia Royal Brisbane Hosp Brisbane Qld Australia 4029 029, Australia
Citazione:
T.J. Morgan et al., "Reduced red cell 2,3-diphosphoglycerate concentrations in critical illnesswithout decreased in vivo P50", ANAESTH I C, 29(5), 2001, pp. 479-483

Abstract

We investigated whether red cell 2,3-diphosphoglycerate (2,3-DPG) concentrations are reduced in critical illness, whether acidaemia, hypophosphataemia or anaemia influence 2,3-DPG, and whether there is any net effect on in vivo P50. Twenty healthy, non-smoking, male volunteers were compared with 20 male intensive care patients with APACHE 2 scores > 20 on the preceding day. Thosetransfused in this time were excluded. Venous red cell 2,3-DPG concentrations were measured in both groups. In the patient group, routine multichannel biochemical profile and arterial blood gas analysis were also performed and in vivo P50 calculated. The mean 2,3-DPG concentration was significantly lower in the patient group than in the controls (4.2 +/-1.3 mmoll/l vs 4.9 +/-0.5 mmol/l, P=0.016). The patients were well oxygenated (lowest arterial PO2=75 mm Hg) and showeda tendency to acidaemia (median pH 7.37, range 7.06 to 7.48) and anaemia (median haemoglobin concentration 113 g/l, range 89 to 154 g/l). By linear regression of patient data, pH had a significant effect on 2,3-DPG concentrations (r=0.6, P=0.011). Haemoglobin and phosphate concentrations did not, but there were few abnormal phosphate values. There was no correlation between 2,3-DPG concentrations and in vivo P50 (r(2) less than or equal to 0.08). We conclude that 2,3-DPG concentrations were reduced in a broad group of critically ill patients. Although this would normally reduce the P50, the reduction was primarily linked with acidaemia, which increases the P50. Overall, there was no net effect on the P50 and thus no affinity-related decrease in tissue oxygenation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:56:18