Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Non-CAA angiopathies and their possible interactions with cerebral amyloidangiopathy
Autore:
Vinters, HV; Wang, ZZ;
Indirizzi:
Univ Calif Los Angeles, Ctr Med, Dept Pathol & Lab Med, Sect Neuropathol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Neurol, Ctr Med, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Ctr Med, Inst Neuropsychiat, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA
Titolo Testata:
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
, volume: 8, anno: 2001, supplemento:, 1
pagine: 2 - 9
SICI:
1350-6129(200107)8:<2:NAATPI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECURSOR PROTEIN; DUTCH TYPE; HCHWA-D; MICROVASCULAR DEGENERATION; SMOOTH-MUSCLE; HEMORRHAGE; BRAIN; DISEASE; ENCEPHALOPATHY; ACCUMULATION;
Keywords:
amyloid angiopathy; arteriopathy; microangiopathy; hypertensive; arteriosclerosis; atherosclerosis; CADASIL; Binswanger subcortical leukoencephalopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Vinters, HV Univ Calif Los Angeles, Ctr Med, Dept Pathol & Lab Med, Sect Neuropathol, CHS 18-17, Los Angeles, CA 90095 USA Univ Calif Los Angeles CHS18-17 Los Angeles CA USA 90095 USA
Citazione:
H.V. Vinters e Z.Z. Wang, "Non-CAA angiopathies and their possible interactions with cerebral amyloidangiopathy", AMYLOID, 8, 2001, pp. 2-9

Abstract

Cerebral amyloid angiopathy (CAA) is one of the two most common cerebral arteriopathies seen in the brains of elderly patients. The other is arteriosclerosis (AS), historically considered a consequence of chronic hypertension and also described as lipohyalinosis (LH), a clinicopathologic association that is increasingly questioned. These and other less frequently encountered degenerations of the cerebral microvasculature (CADASIL, Binswanger subcortical leukoencephalopathy) share the common feature of degeneration of the medial smooth muscle layer within arteriolar walls. This can be dramaticin CAA, in the course of which complete replacement of medial smooth muscle by, fibrillar amyloid may occur It is a less prominent feature of CADASILand BSLE; in the latter condition, medial smooth muscle hyperplasia, possibly a response to some kind of injury, is a more dramatic finding. In some of these "angiomyopathies", fibrinoid necrosis of the arterial wall and microaneurysm formation may lead to stroke, manifest as cerebral hemorrhage. With CADASIL and BSLE, ischemic brain injury is more common. In the case of CAA upregulation of the A beta -amyloid precursor protein occurs when arteriolar smooth muscle cells in culture are exposed to prolonged hypoxia, especially, with reoxygenation. Injury, to arteriolar smooth muscle cells may be one mechanism by which angiomyopathies progress and become symptomatic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:56:13