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Titolo:
CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model
Autore:
Wang, SZ; Rosenberger, CL; Espindola, TM; Barrett, EG; Tesfaigzi, Y; Bice, DE; Harrod, KS;
Indirizzi:
Lovelace Resp Res Inst, Asthma & Pulm Immunol Program, Albuquerque, NM 87185 USA Lovelace Resp Res Inst Albuquerque NM USA 87185 Albuquerque, NM 87185 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: L1303 - L1311
SICI:
1040-0605(200111)281:5<L1303:CMADAH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; PROTEIN-DEFICIENT MICE; EPITHELIAL-CELLS; EXPRESSION; ASTHMA; LUNG; NEUTROPHILS; INFECTION; GENE; HYPERRESPONSIVENESS;
Keywords:
Clara cell secretory protein; lung epithelium; asthma; ovalbumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Harrod, KS Lovelace Resp Res Inst, Asthma & Pulm Immunol Program, Albuquerque, NM 87185 USA Lovelace Resp Res Inst Albuquerque NM USA 87185 , NM 87185 USA
Citazione:
S.Z. Wang et al., "CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model", AM J P-LUNG, 281(5), 2001, pp. L1303-L1311

Abstract

Clara cell secretory protein (CCSP) is synthesized by nonciliated bronchiolar cells in the lung and modulates lung inflammation to infection. To determine the role of CCSP in the host response to allergic airway disease, CCSP-deficient [(-/-)] mice were immunized twice with ovalbumin (Ova) and challenged by Ova (2 or 5 mg/m(3)) aerosol. After 2, 3, and 5 days of Ova aerosol challenge (6 h/day), airway reactivity was increased in CCSP(-/-) mice compared with wild-type [CCSP(+/+)]mice. Neutrophils were markedly increasedin the bronchoalveolar lavage fluid of CCSP(-/-) Ova mice, coinciding withincreased myeloperoxidase activity and macrophage inflammatory protein-2 levels. Lung histopathology and inflammation were increased in CCSP(-/-) compared with wild-type mice after Ova challenge. Mucus production, as assessed by histological staining, was increased in the airway epithelium of CCSP(-/-) Ova mice compared with that in CCSP(+/+) Ova mice. These data suggest a role for CCSP in airway reactivity and the host response to allergic airway inflammation and provide further evidence for the role of the airway epithelium in regulating airway responses in allergic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:15:16