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Titolo:
Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow
Autore:
Gutierrez, JA; Parry, AJ; McMullan, DM; Chapin, CJ; Fineman, JR;
Indirizzi:
Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: L1264 - L1270
SICI:
1040-0605(200111)281:5<L1264:DSPILW>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL HEART-DISEASE; MESSENGER-RNA LEVELS; FETAL LUNG INVITRO; A-DEFICIENT MICE; ENDOTHELIAL-CELLS; SHEAR-STRESS; RESPIRATORY-FAILURE; SP-B; SP-C; EXPRESSION;
Keywords:
congenital heart disease; gene expression; overcirculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gutierrez, JA Univ Calif San Francisco, Dept Pediat, 3333 Calif St,Box 1245, San Francisco, CA 94118 USA Univ Calif San Francisco 3333 Calif St,Box 1245 San Francisco CA USA 94118
Citazione:
J.A. Gutierrez et al., "Decreased surfactant proteins in lambs with pulmonary hypertension secondary to increased blood flow", AM J P-LUNG, 281(5), 2001, pp. L1264-L1270

Abstract

Infants with increased pulmonary blood flow secondary to congenital heart disease suffer from tachypnea, dyspnea, and recurrent pulmonary infections. We have recently established a model of pulmonary hypertension secondary to increased pulmonary blood flow in lambs after in utero placement of an aortopulmonary vascular graft. The purpose of the present study was to utilize our animal model to determine the effects on the expression of surfactantproteins A (SP-A), B (SP-B), and C (SP-C). At age 4 wk, SP-A mRNA content in lambs decreased to 61.4 +/- 8% of age-matched control value (n = 5; P < 0.05). In addition, SP-A protein content was decreased to 50 <plus/minus> 12% of control value (n 5 6; P < 0.0001). Although we did not observe statistically significant changes in SP-B mRNA content, SP-B protein was decreased to 74 <plus/minus> 25% of control value (n = 4; P < 0.02). There was no difference in SP-C mRNA. These data show that in a model of congenital heartdisease with pulmonary hypertension secondary to increased pulmonary bloodflow, there is a decrease in SP-A gene expression as well as a decrease inSP-A and SP-B protein contents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:23:52