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Titolo:
The vagus is inhibitory of insulin secretion under fasting conditions
Autore:
Blat, S; Malbert, CH;
Indirizzi:
INRA, Unite Mixte Rech Veau & Porc, F-35590 St Gilles, France INRA St Gilles France F-35590 ech Veau & Porc, F-35590 St Gilles, France
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 4, volume: 281, anno: 2001,
pagine: E782 - E788
SICI:
0193-1849(200110)281:4<E782:TVIIOI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFERENT NERVE-FIBERS; CONSCIOUS DOGS; BLOOD-GLUCOSE; BETA-CELLS; RAT; VAGOTOMY; RELEASE; SYSTEM; BLOCKADE; STIMULATION;
Keywords:
vagal cooling; splanchnicotomy; interdigestive state; insulin release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Malbert, CH INRA, Unite Mixte Rech Veau & Porc, F-35590 St Gilles, France INRA St Gilles France F-35590 orc, F-35590 St Gilles, France
Citazione:
S. Blat e C.H. Malbert, "The vagus is inhibitory of insulin secretion under fasting conditions", AM J P-ENDO, 281(4), 2001, pp. E782-E788

Abstract

The involvement of the vagus in the insulin response during the early phase of absorption of a meal has been demonstrated recently. The extent of this vagal influence was investigated during fasting in an anesthetized porcine model. Portal and systemic insulin were evaluated together with glycemia during cooling and sectioning of both cervical vagal trunks in 12 splanchnicotomized or sham-operated pigs. In sham-operated animals, portal and systemic insulin were significantly and reversibly increased by cooling (173 and123%, respectively). Portal insulin peaked 20 min after the onset of cooling but declined slowly while cooling was still activated. In contrast, systemic insulin was increased evenly along cooling. Section of the vagus was also associated with a portal and systemic insulin increase (144 and 117%) but to a lesser extent than cooling. In both treatments, portal and systemicinsulin increases were either reduced (vagal cooling) or eliminated (vagalsection) in splanchnicotomized animals. We conclude that the vagus exerts an inhibitory activity on interdigestive insulin secretion that is partly mediated by the splanchnic nerves.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:15:11