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Titolo:
Myosin XVA expression in the pituitary and in other neuroendocrine tissuesand tumors
Autore:
Lloyd, RV; Vidal, S; Jin, L; Zhang, SY; Kovacs, K; Horvath, E; Scheithauer, BW; Boger, ETA; Fridell, RA; Friedman, TB;
Indirizzi:
Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Fdn, Rochester, MN 55905 USA Univ Santiago de Compostela, Lugo, Spain Univ Santiago de Compostela Lugo Spain tiago de Compostela, Lugo, Spain St Michaels Hosp, Toronto, ON M5B 1W8, Canada St Michaels Hosp Toronto ONCanada M5B 1W8 p, Toronto, ON M5B 1W8, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada Natl Inst Deafness & Other Commun Disorders, Mol Genet Lab, NIH, Rockville, MD USA Natl Inst Deafness & Other Commun Disorders Rockville MD USA lle, MD USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 4, volume: 159, anno: 2001,
pagine: 1375 - 1382
SICI:
0002-9440(200110)159:4<1375:MXEITP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-CHAIN KINASE; UNCONVENTIONAL MYOSIN; DEAFNESS DFNB3; CHROMOGRANIN-A; GROWTH-FACTOR; SUPERFAMILY; SHAKER-2; REGION; LOCALIZATION; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lloyd, RV Mayo Fdn, Lab Med & Pathol, Rochester, MN 55905 USA Mayo Fdn Rochester MN USA 55905 Pathol, Rochester, MN 55905 USA
Citazione:
R.V. Lloyd et al., "Myosin XVA expression in the pituitary and in other neuroendocrine tissuesand tumors", AM J PATH, 159(4), 2001, pp. 1375-1382

Abstract

The myosin superfamily of molecular motor proteins includes conventional myosins and several classes of unconventional myosins. Recent studies have characterized the human and mouse unconventional myosin XVA, which has a role in the formation and/or maintenance of the unique actin-rich structures of inner ear sensory hair cells. Myosin XVA is also highly expressed in human anterior pituitary cells. In this study we examined the distribution of myosin XVA protein and mRNA in normal and neoplastic human pituitaries and other neuroendocrine cells and tumors. Myosin XVA was expressed in all typesof normal anterior pituitary cells and pituitary tumors and in other neuroendocrine cells and tumors including those of the adrenal medulla, parathyroid, and pancreatic islets. Most nonneuroendocrine tissues examined including liver cells were negative for myosin XVA protein and mRNA, although the distal and proximal tubules of normal kidneys showed moderate immunoreactivity for myosin XVA. Ultrastructural immunohistochemistry localized myosin XVA in association with secretory granules of human anterior pituitary cellsand human pituitary tumors. These data suggest that in neuroendocrine cells myosin XVA may have a role in secretory granule movement and/or secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:01:05