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Titolo:
Hypoxia in human prostate carcinoma - An Eppendorf Po-2 study
Autore:
Movsas, B; Chapman, JD; Hanlon, AL; Horwitz, EM; Pinover, WH; Greenberg, RE; Stobbe, C; Hanks, GE;
Indirizzi:
Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Radiat Oncol Stat, Philadelphia, PA 19111 USA FoxChase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Surg Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
fascicolo: 5, volume: 24, anno: 2001,
pagine: 458 - 461
SICI:
0277-3732(200110)24:5<458:HIHPC->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; TUMOR HYPOXIA; PROGRESSION; THERAPY; HEAD; NECK;
Keywords:
prostate carcinoma; hypoxia; Eppendorf Po-2 microelectrode;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Movsas, B Fox Chase Canc Ctr, Dept Radiat Oncol, 7701 Burholme Ave, Philadelphia, PA19111 USA Fox Chase Canc Ctr 7701 Burholme Ave Philadelphia PA USA 19111 A
Citazione:
B. Movsas et al., "Hypoxia in human prostate carcinoma - An Eppendorf Po-2 study", AM J CL ONC, 24(5), 2001, pp. 458-461

Abstract

The purpose of this study was to characterize the extent of hypoxia in human prostate carcinoma using the Eppendorf Po-2 microelectrode. Custom-made Eppendorf Po2 microelectrodes were used to obtain Po-2 measurements from the pathologically involved region of the prostate (as determined by the pretreatment sextant biopsies), as well as from a region of normal muscle for comparison. Fifty-nine patients with localized prostate cancer were studied,all of whom received brachytherapy implants under spinal anesthesia. A multivariate mixed effects analysis for prediction of tumor oxygenation was performed including the following covariates: type of tissue (prostate versusmuscle), prostatic-specific antigen, disease stage, patient age and race, tumor grade, volume, perineural invasion, and hormonal therapy. Because of differences in patient characteristics, control measurements were obtained from normal muscle in all patients. This internal comparison showed that the oxygen measurements from the pathologically involved portion of the prostate were significantly lower (average median Po-2 = 2.4 mm Hg) compared with the measurements from normal muscle (average median Po-2 = 30.0 mm. Hg), p < 0.0001. A multivariate, linear, mixed analysis demonstrated that the only significant predictor of oxygenation was the type of tissue (prostate versus muscle). This study, using in vivo electrode oxygen measurements, suggests that hypoxia exists in human prostate carcinoma. More patients will beaccrued to this study to ultimately correlate the oxygenation status in prostate carcinoma tunors with treatment outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:07:31