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Titolo:
Anticonvulsive prophylaxis of posttraumatic epilepsy in childhood
Autore:
Kieslich, M; Born, A; Jacobi, G;
Indirizzi:
Univ Frankfurt, Klin 1, Zentrum Kinderheilkunde & Jugendmed, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 med, D-60590 Frankfurt, Germany
Titolo Testata:
AKTUELLE NEUROLOGIE
fascicolo: 7, volume: 28, anno: 2001,
pagine: 313 -
SICI:
0302-4350(200109)28:7<313:APOPEI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
GER
Soggetto:
PROPHYLACTICALLY ADMINISTERED PHENYTOIN; POST-TRAUMATIC EPILEPSY; SEVERE BRAIN INJURIES; RISK-FACTORS; FOLLOW-UP; SEIZURES; PREVENTION; TOPIRAMATE; FAILURE; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kieslich, M Univ Frankfurt, Klin 1, Zentrum Kinderheilkunde & Jugendmed, Theodor SternKai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
M. Kieslich et al., "Anticonvulsive prophylaxis of posttraumatic epilepsy in childhood", AKT NEUROL, 28(7), 2001, pp. 313

Abstract

There is still a considerable controversy about the usefullness of antiepileptic prophylaxis after traumatic brain injury. Antiepileptic treatment seems to be effective in preventing early posttraumatic seizures. The published data concerning the effect on late posttraumatic seizures are varying. Most of the studies are based on adult patients and it implies difficulties to transfer these results to the paediatric population. Methods: A retrospective analysis of the data of 318 children with civilian brain injuries wasperformed. The mean age was 6 years and 3 months, the mean follow-up was 9years. A subgroup of 44 patients was initially treated intravenously with phenobarbitone. Another subgroup of 164 patients received phenobarbitone orcarbamazepine for two years after the accident. Results: The overall incidence of early seizures was 19.8%, of late seizures 21.4%. Main risk factorsfor the development of late seizures were early seizures, age at accident under 2 years, subdural intracranial haemorrhages and brain injuries in battered child syndrom. Patients with initial intravenous phenobarbitone treatment had significantly less early seizures (6.8% against 30.2%; p < 0.05). Patients receiving antiepileptic treatment for two years prophylactically showed no significantly lower incidences of late seizures (24.4% against 33.3%; p = 0.253). Conclusions: Initial posttraumatic antiepileptic treatment can reduce early posttraumatic seizures in children. There is no significant preventive effect on late seizures, a risk adapted procedure is recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:22:42