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Titolo:
Highly active antiretroviral therapy associated with improved anemia amongHIV-infected women
Autore:
Semba, RD; Shah, N; Klein, RS; Mayer, KH; Schuman, P; Gardner, LI; Vlahov, D;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA , Dept Ophthalmol, Baltimore, MD USA Johns Hopkins Univ, Sch Med, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA d, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA h, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Ophthalmol, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA , Dept Ophthalmol, Baltimore, MD USA Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 Med, Dept Med, Bronx, NY 10467 USA Brown Univ, Dept Med, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 iv, Dept Med, Providence, RI 02912 USA Wayne State Univ, Dept Med, Detroit, MI 48202 USA Wayne State Univ Detroit MI USA 48202 iv, Dept Med, Detroit, MI 48202 USA Ctr Dis Control & Prevent, Div HIV AIDS, Atlanta, GA USA Ctr Dis Control &Prevent Atlanta GA USA , Div HIV AIDS, Atlanta, GA USA New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA New York Acad Med New York NY USA an Epidemiol Studies, New York, NY USA
Titolo Testata:
AIDS PATIENT CARE AND STDS
fascicolo: 9, volume: 15, anno: 2001,
pagine: 473 - 480
SICI:
1087-2914(200109)15:9<473:HAATAW>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; TUMOR-NECROSIS-FACTOR; SOCIETY-USA PANEL; HEMATOLOGIC ABNORMALITIES; UPDATED RECOMMENDATIONS; PROTEASE INHIBITORS; AIDS; CELLS; ERYTHROPOIETIN; HEMATOPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Semba, RD 550 N Broadway,Suite 700, Baltimore, MD 21205 USA 550 N Broadway,Suite 700 Baltimore MD USA 21205 e, MD 21205 USA
Citazione:
R.D. Semba et al., "Highly active antiretroviral therapy associated with improved anemia amongHIV-infected women", AIDS PAT CA, 15(9), 2001, pp. 473-480

Abstract

Anemia is common during human immunodeficiency virus (HIV) infection and is associated with increased mortality. We conducted a study to examine the impact of highly active antiretroviral therapy (HAART) on anemia in a multicenter cohort of HIV-positive women, the Human Immunodeficiency Virus Epidemiology Research (HER) Study. Among women receiving HAART (n = 188), non-HAART monotherapy or combination antiretroviral therapy (ART) (n = 111), or who had no reported treatment (n = 62), the prevalence of anemia (hemoglobin, <120 g/L) at baseline was 38.3, 36.9, and 43.6%, respectively (p = 0.58) and at 1-year follow-up was 26.1%, 36.9%, 45.2%, respectively (p = 0.01); mean hemoglobin at baseline was 125 +/- 16, 122 +/- 16, and 122 +/- 18 g/L, respectively (p = 0.29) and at 1-year follow-up was 128 +/- 14, 123 +/- 16,and 119 +/- 20 g/L, respectively (p < 0.0001). Adjusted linear regression models showed that HAART was associated with an increase of hemoglobin of 0.20 g/L per month (p = 0.007). After 1 year of treatment, HAART was associated with a 32% reduction in anemia among HIV-infected women (p = 0.01), whereas there was no significant change in the prevalence of anemia among those on non-HAART ART or those who had no reported treatment. HAART is associated with a large reduction in anemia among HIV-infected women.

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Documento generato il 10/04/20 alle ore 16:03:54