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Titolo:
The epidemiology of HSV-2 infection and its association with HIV infectionin four urban African populations
Autore:
Weiss, HA; Buve, A; Robinson, NJ; Van Dyck, E; Kahindo, M; Anagonou, S; Musonda, R; Zekeng, L; Morison, L; Carael, M; Laga, M; Hayes, RJ;
Indirizzi:
Univ London London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, London WC1E 7HT, England Univ London London Sch Hyg & Trop Med London England WC1E 7HT T, England
Titolo Testata:
AIDS
, volume: 15, anno: 2001, supplemento:, 4
pagine: S97 - S108
SICI:
0269-9370(200108)15:<S97:TEOHIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX VIRUS TYPE-2; HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED DISEASES; RURAL UGANDAN POPULATION; GENITAL ULCER DISEASE; RISK FACTOR; HAEMOPHILUS-DUCREYI; NORTHERN THAILAND; HOMOSEXUAL MEN; HERPES;
Keywords:
herpes simplex virus type-2 infection; epidemiology; Africa; risk factors; heterosexual transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, HA Univ London London Sch Hyg & Trop Med, Infect Dis Epidemiol Unit, Keppel St, London WC1E 7HT, England Univ London London Sch Hyg & Trop MedKeppel St London England WC1E 7HT
Citazione:
H.A. Weiss et al., "The epidemiology of HSV-2 infection and its association with HIV infectionin four urban African populations", AIDS, 15, 2001, pp. S97-S108

Abstract

Objectives: To estimate age- and sex-specific herpes simplex virus type-2 (HSV-2) prevalence in urban African adult populations and to identify factors associated with infection. Design and methods: Cross-sectional, population-based samples of about 2000 adults interviewed in each of the following cities: Cotonou, Benin; Yaounde, Cameroon; Kisumu, Kenya and Ndola, Zambia. Consenting study participants were tested for HIV, HSV-2 and other sexually, transmitted infections. Results: HSV-2 prevalence was over 50% among women and over 25% among men in Yaounde, Kisumu and Ndola, with notably high rates of infection among young women in Kisumu and Ndola (39% and 23%, respectively, among women aged 15-19 years). The prevalence in Cotonou was lower (30% in women and 12% in men). Multivariate analysis showed that HSV-2 prevalence was significantly associated with older age, ever being married, and number of lifetime sexual partners, in almost all cities and both sexes. There was also a strong, consistent association with HIV infection. Among women, the adjusted odds ratios for the association between HSV-2 and HIV infections ranged from 4.0 [95% confidence interval (CI) = 2.0-8.0] in Kisumu to 5.5 (95% CI = 1.7-18) in Yaounde, and those among men ranged from 4.6 (95% Cl = 2.7-7.7) in Ndolato 7.9 (95% Cl = 4.1-15) in Kisumu. Conclusions: HSV-2 infection is highly prevalent in these populations, even at young ages, and is strongly associated with HIV at an individual level. At a population level, HSV-2 prevalence was highest in Kisumu and Ndola, the cities with the highest HIV rates, although rates were also high among women in Yaounde, where there are high rates of partner change but relatively little HIV infection. The high prevalence of both infections among youngpeople underlines the need for education and counselling among adolescents. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:12:45