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Titolo:
The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats
Autore:
Nieckarz, JA; Daniel, GB;
Indirizzi:
Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, Knoxville, TN 37901 USA Univ Tennessee Knoxville TN USA 37901 m Clin Sci, Knoxville, TN 37901 USA Univ Tennessee, Coll Vet Med, Dept Large Anim Clin Sci, Knoxville, TN 37901 USA Univ Tennessee Knoxville TN USA 37901 m Clin Sci, Knoxville, TN 37901 USA
Titolo Testata:
VETERINARY RADIOLOGY & ULTRASOUND
fascicolo: 5, volume: 42, anno: 2001,
pagine: 448 - 457
SICI:
1058-8183(200109/10)42:5<448:TEOMOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOACTIVE IODINE THERAPY; FELINE HYPERTHYROIDISM; SCINTIGRAPHY; THYROXINE; GLAND; I-131;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Daniel, GB Univ Tennessee, Coll Vet Med, Dept Small Anim Clin Sci, POB 1071, Knoxville, TN 37901 USA Univ Tennessee POB 1071 Knoxville TN USA 37901 le, TN 37901 USA
Citazione:
J.A. Nieckarz e G.B. Daniel, "The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats", VET RAD ULT, 42(5), 2001, pp. 448-457

Abstract

Many hyperthyroid cats referred for thyroid imaging and I-131 therapy are concurrently or recently receiving antithyroid medications. The effect of the antithyroid drug, methimazole, on thyroid uptake of (TcO4)-Tc-99m and I-123 was evaluated in 8 normal cats. Quantitative analysis was used to determine the normal percent dose uptake of (TcO4)-Tc-99m and I-123, the change in thyroid: salivary ratios (T:S) of (TcO4)-Tc-99m over time, and the duration of the methimazole effect on thyroid uptake of I-123. Methimazole was administered to 5 cats for 3 weeks in which a hypothyroid state was obtained; 3 cats served as non-treatment controls. (TcO4)-Tc-99m and 8 and 24 hour I-123 imaging was repeated after 3 weeks of methimazole therapy (time of maximum T-4 suppression). Methimazole was then discontinued and I-123 images and serum T4 concentrations were repeated at 1, 4, 9, 15, and 24 days post withdrawal. The percent dose uptake of (TcO4)-Tc-99m increased throughout the acquisition period with maximum uptake occurring 4 hour post injection. The baseline 20 min. T:S ratio for controls and treatment cats were 0.79 +/- 0.08 and 0.81 +/- 0.05 respectively; with a peak value of 1.29 +/- 0.23 and 1.31 +/- 0.18 at 4 hours. The baseline T:S ratios were not significantlydifferent from 20 minutes to 2 hours, however they were significantly elevated at 4 hours post injection. Baseline, 8 and 24 hour percent dose uptakeof I-123 were 2.1 +/- 0.42% and 7.04 +/- 1.24%, respectively. There was a significant increase in the T:S ratio in the treatment group at all time points. The 8 hour percent dose uptake of I-123 at 1, 4, and 9 days post methimazole withdrawal were significantly increased and peaked at 4 days. The 24 hour uptake was significantly increased at 4 and 9 days, with peak uptakeat 9 days post-methimazole withdrawal. The I-123 percent dose uptake decreased to baseline values by day 15 post withdrawal. Radioiodine uptake is not inhibited by methimazole treatment in normal cats, and is significantly enhanced after recent withdrawal. This finding is supportive of a "short term rebund effect" with maximal enhanced uptake between 4 and 9 days after discontinuing antithyroid drugs. The increased uptake of (TcO4)-Tc-99m may also affect the interpretation of (TcO4)-Tc-99m thyroid scintigraphy for 2-3 weeks.

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Documento generato il 06/04/20 alle ore 08:46:03