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Titolo:
Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required
Autore:
Vorwerk, CK; Naskar, R; Schuettauf, F; Zurakowski, D; McDermott, LM; Quinto, KM; Dreyer, EB;
Indirizzi:
Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 phthalmol, Philadelphia, PA 19104 USA Vet Adm, Philadelphia, PA 19104 USA Vet Adm Philadelphia PA USA 19104Vet Adm, Philadelphia, PA 19104 USA Childrens Hosp, Dept Biostat, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 sp, Dept Biostat, Boston, MA 02115 USA
Titolo Testata:
VETERINARY OPHTHALMOLOGY
fascicolo: 3, volume: 4, anno: 2001,
pagine: 201 - 204
SICI:
1463-5216(200109)4:3<201:ECBMTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; RAT MODEL; PARKINSONS-DISEASE; NITRIC-OXIDE; ADULT-RATS; MEMANTINE; DEGENERATION; DISCRIMINATION; GLUTAMATE; ISCHEMIA;
Keywords:
axotomy; excitotoxicity; NMDA; retinal ganglion cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dreyer, EB Univ Penn, Scheie Eye Inst, Dept Ophthalmol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Philadelphia, PA 19104 USA
Citazione:
C.K. Vorwerk et al., "Excitotoxicity can be mediated through an interaction within the optic nerve; activation of cell body NMDA receptors is not required", VET OPHTHAL, 4(3), 2001, pp. 201-204

Abstract

Axonal trauma leads to a series of pathologic events that can culminate inneuronal death. Although the precise mechanisms of retinal ganglion cell death after optic nerve crush in the rat model have not been elucidated, glutamate antagonists can protect retinal ganglion cells after optic nerve axotomy. We therefore explored whether a glutamate congener was toxic if applied directly within the optic nerve, or if toxicity depended upon an interaction at the cell body level. NMDA reduced retinal ganglion cell survival when applied directly into the rat optic nerve. Glutamate can be toxic if administered within the optic nerve; a direct effect at the cell body is not necessary. Future work will help to additionally unravel the steps by which axotomy induces excitotoxic damage to ganglion cells, and perhaps indicate protective interventions.

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Documento generato il 27/01/20 alle ore 18:04:12