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Titolo:
The dual role of CTLA-4 in Leishmania infection
Autore:
Gomes, NA; DosReis, GA;
Indirizzi:
Fiocruz MS, Inst Oswaldo Cruz, BR-21045900 Rio De Janeiro, Brazil Fiocruz MS Rio De Janeiro Brazil BR-21045900 BC00 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Carlos Chagas Filho Inst Biophys, BR-21944970 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21944970 BCeiro, Brazil
Titolo Testata:
TRENDS IN PARASITOLOGY
fascicolo: 10, volume: 17, anno: 2001,
pagine: 487 - 491
SICI:
1471-4922(200110)17:10<487:TDROCI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; GROWTH-FACTOR-BETA; MURINE VISCERAL LEISHMANIASIS; TGF-BETA; MAJOR INFECTION; IN-VIVO; COSTIMULATORY MOLECULES; BALB/C MICE; TH2 CELLS; EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Gomes, NA Fiocruz MS, Inst Oswaldo Cruz, Av Brasil 4365, BR-21045900 Rio De Janeiro,Brazil Fiocruz MS Av Brasil 4365 Rio De Janeiro Brazil BR-21045900 BCl
Citazione:
N.A. Gomes e G.A. DosReis, "The dual role of CTLA-4 in Leishmania infection", TRENDS PARA, 17(10), 2001, pp. 487-491

Abstract

The role of CTLA-4 in inducing the production of transforming growth factor beta (TGF-beta) from T cells during a Leishmania infection has only recently been recognized. However, CTLA-4 and TGF-beta affect T helper cells differently, depending on the maturation. This review discusses the data obtained from different experimental models and demonstrates that CTLA-4 is a target molecule for vaccination and therapy against leishmaniasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 20:53:46