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Titolo:
EXPERIMENTAL SYRINGOMYELIA IN THE RABBIT - AN ULTRASTRUCTURAL-STUDY OF THE SPINAL-CORD TISSUE
Autore:
CHAKRABORTTY S; TAMAKI N; EHARA K; IDE C;
Indirizzi:
KOBE UNIV,SCH MED,DEPT NEUROSURG,7-5-1 KUSUNOKI CHO KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT NEUROSURG KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT ANAT KOBE 650 JAPAN
Titolo Testata:
Neurosurgery
fascicolo: 6, volume: 35, anno: 1994,
pagine: 1112 - 1120
SICI:
0148-396X(1994)35:6<1112:ESITR->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL HYDROCEPHALUS; COMMUNICATING SYRINGOMYELIA; BRAIN-DAMAGE; PATHOGENESIS; MORPHOLOGY; EPENDYMA; EDEMA; RATS; DOGS;
Keywords:
DEMYELINATION; RABBIT; REMYELINATION; SPINAL CORD; SYRINGOMYELIA; ULTRASTRUCTURAL CHANGE; WHITE MATTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
S. Chakrabortty et al., "EXPERIMENTAL SYRINGOMYELIA IN THE RABBIT - AN ULTRASTRUCTURAL-STUDY OF THE SPINAL-CORD TISSUE", Neurosurgery, 35(6), 1994, pp. 1112-1120

Abstract

HYDROSYRINGOMYELIA WAS PRODUCED experimentally by the injection of kaolin into the cisterna magna of the rabbit, and the ultrastructural changes of the spinal cord surrounding the syrinx were investigated 2, 4, and 6 weeks after injection by transmission electron microscopy. Theependyma at the ventral part of the central canal was flat and stretched, whereas, in the dorsal part, it was split, and the syrinx extended through the dorsal median plane in most animals. Extracellular edemawas found in the subependymal white matter and in and around the posterior median septum. Many nerve fibers surrounding the syrinx were in varying stages of axonal degeneration. Myelin sheaths were split, thinned, and completely lost in many nerve fibers. In some fibers, the axons were totally lost, leaving the myelin sheaths as empty tubes. Astrocytic processes containing a large number of glial filaments covered the nerve fibers adjacent to the syrinx and partially replaced the edematous area. The perivascular spaces were enlarged, especially near thesyrinx and in the dorsal white matter. Oligodendrocytes remained undamaged, and the remyelination by oligodendrocytic processes was seen onsome denuded axons. Sometimes, this further remyelination was abortive, especially where the edema was severe. The ultrastructural changes of the neural tissue and their sequences were identical, in most respects, to those of hydrocephalus and noncommunicating syringomyelia. Theoligodendrocytic remyelination with ongoing demyelination found in this model has many similarities to those in experimental hydrocephalus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:05:23