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Titolo:
The evolving role of propionibacterium acnes in acne
Autore:
Leyden, JJ;
Indirizzi:
Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dermatol, Philadelphia, PA 19104 USA
Titolo Testata:
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 139 - 143
SICI:
1085-5629(200109)20:3<139:TEROPA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERYTHROMYCIN RESISTANCE; COMPLEMENT ACTIVATION; VULGARIS; TETRACYCLINE; MINOCYCLINE; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Leyden, JJ Univ Penn, Dept Dermatol, 3400 Spruce St,2 Ravin, Philadelphia,PA 19104 USA Univ Penn 3400 Spruce St,2 Ravin Philadelphia PA USA 19104 USA
Citazione:
J.J. Leyden, "The evolving role of propionibacterium acnes in acne", SEM CUT M S, 20(3), 2001, pp. 139-143

Abstract

Propionibacterium acnes is a member of the resident cutaneous flora. Sebaceous follicles involved in acne are characterized by the accumulation of abnormally desquamated corneocytes and excess sebum-the microcomedo. This environment provides ideal growth conditions for P acnes. Several orders of magnitude level of P acnes are found in microcomedos. P acnes produces a variety of chemotactic factors and proinflammatory molecules that are responsible for the inflammatory phase of acne. Antibiotic therapy works by reducingthe viable number of P acnes as well as by reducing the production of inflammatory stimuli. Antibiotic therapy has been a mainstay of treatment for more than 30 years. In the last decade, decreased sensitivity to antibioticshas developed and clinical resistance has been described. This developmentthreatens the usefulness of antibiotic therapy in the future. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:13:35