Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
An apolipoprotein influencing triglycerides in humans and mice revealed bycomparative sequencing
Autore:
Pennacchio, LA; Olivier, M; Hubacek, JA; Cohen, JC; Cox, DR; Fruchart, JC; Krauss, RM; Rubin, EM;
Indirizzi:
Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ci Dept, Berkeley, CA 94720 USA Stanford Univ, Sch Med, Dept Genet, Stanford Human Genome Ctr, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 Genome Ctr, Palo Alto, CA 94304 USA Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Ctr Human Nutr, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390USA Univ Texas Dallas TX USA 75390 tr Human Growth & Dev, Dallas, TX 75390USA Inst Pasteur, Dept Atherosclerosis, INSERM, U545, F-59019 Lille, France Inst Pasteur Lille France F-59019 s, INSERM, U545, F-59019 Lille, France Univ Lille, Fac Pharm, F-59006 Lille, France Univ Lille Lille France F-59006 Lille, Fac Pharm, F-59006 Lille, France
Titolo Testata:
SCIENCE
fascicolo: 5540, volume: 294, anno: 2001,
pagine: 169 - 173
SICI:
0036-8075(20011005)294:5540<169:AAITIH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL COMBINED HYPERLIPIDEMIA; C-III GENE; TRANSGENIC MICE; CAUSES HYPERTRIGLYCERIDEMIA; A-II; OVEREXPRESSION; ATHEROSCLEROSIS; IDENTIFICATION; POLYMORPHISMS; ATHEROGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Rubin, EM Univ Calif Berkeley, Lawrence Berkeley Lab, Genome Sci Dept, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 erkeley, CA 94720 USA
Citazione:
L.A. Pennacchio et al., "An apolipoprotein influencing triglycerides in humans and mice revealed bycomparative sequencing", SCIENCE, 294(5540), 2001, pp. 169-173

Abstract

Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized APOAI/CIII/AIV gene cluster on human 11q23. Mice expressing a human APOAV transgene showed a decrease in plasma triglyceride concentrations to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls. In humans, single nucleotide polymorphisms (SNPs) across the APOAV locus were found to be significantly associated with plasma triglyceride levels in two independent studies. These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 12:07:28