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Titolo:
A randomized controlled trial of homeopathy in rheumatoid arthritis
Autore:
Fisher, P; Scott, DL;
Indirizzi:
Univ London Kings Coll Hosp, GKT Sch Med, Dept Rheumatol, London SE22 9PT,England Univ London Kings Coll Hosp London England SE22 9PT don SE22 9PT,England Royal London Homoeopath Hosp, London WC1N 3HR, England Royal London Homoeopath Hosp London England WC1N 3HR n WC1N 3HR, England
Titolo Testata:
RHEUMATOLOGY
fascicolo: 9, volume: 40, anno: 2001,
pagine: 1052 - 1055
SICI:
1462-0324(200109)40:9<1052:ARCTOH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENTARY MEDICINE; PLACEBO; METAANALYSIS;
Keywords:
homeopathy; rheumatoid arthritis; NSAIDs; DMARDs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Scott, DL Univ London Kings Coll Hosp, GKT Sch Med, Dept Rheumatol, LondonSE22 9PT,England Univ London Kings Coll Hosp London England SE22 9PT PT,England
Citazione:
P. Fisher e D.L. Scott, "A randomized controlled trial of homeopathy in rheumatoid arthritis", RHEUMATOLOG, 40(9), 2001, pp. 1052-1055

Abstract

Objective. To test the hypothesis that homeopathy is effective in reducingthe symptoms of joint inflammation in rheumatoid arthritis (RA). Method. This was a 6-month randomized, cross-over, double-blind, placebo-controlled, single-centre study set in a teaching hospital rheumatology out-patient clinic. The participants of the study were 112 patients who had definite or classical RA, were seropositive for rheumatoid factor and were receiving either stable doses of single non-steroidal anti-inflammatory drugs (NSAIDs) for greater than or equal to3 months or single disease-modifying anti-rheumatic drugs (DMARDs) with or without NSAIDs for greater than or equal to6 months. Patients who were severely disabled, had taken systemic steroids in the previous 6 months or had withdrawn from DMARD therapy in the previous 12 months were excluded. Two series of medicines were used. One comprised 42 homeopathic medicines used for treating RA in 6cH (10(-12)) and/or30cH (10(-30)) dilutions (a total of 59 preparations) manufactured to French National Pharmacopoeia standards, the other comprised identical matchingplacebos. The main outcome measures were visual analogue scale pain scores, Ritchie articular index, duration of morning stiffness and erythrocyte sedimentation rate (ESR). Results. Fifty-eight patients completed the trial. Over 6 months there were significant decreases (P <0.01 by Wilcoxon rank sum tests) in their mean pain scores (fell 18%), articular indices (fell 24%) and ESRs (fell 11%). Fifty-four patients withdrew before completing the trial. Thirty-one changedconventional medication, 10 had serious intercurrent illness or surgery, 12 failed to attend and three withdrew consent. Placebo and active homeopathy had different effects on pain scores; mean pain scores were significantlylower after 3 months' placebo therapy than 3 months' active therapy (P=0.032 by Wilcoxon rank sum test). Articular index, ESR and morning stiffness were similar with active and placebo homeopathy. Conclusions. We found no evidence that active homeopathy improves the symptoms of RA, over 3 months, in patients attending a routine clinic who are stabilized on NSAIDs or DMARDs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 23:01:13